Riociguat Impurity 2 CAS 1361569-10-9
| CAS No. | 1361569-10-9 |
| Molecular Formula | C18H13FN8O |
| Molecular Weight | 376.35 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Riociguat Impurity 2 (CAS 1361569-10-9) is a certified pharmaceutical impurity reference standard with the molecular formula C18H13FN8O and a molecular weight of 376.35 g/mol.
Based on its molecular formula C18H13FN8O, Riociguat Impurity 2 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 376.35 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C18H13FN8O |
| Molecular Weight | 376.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Riociguat Standards
- Riociguat Impurity 1 (CAS 1702271-98-4)
- Riociguat Impurity 16 (CAS 1361569-18-7)
- Riociguat impurity 27 (CAS CATO-C4X-174927)
- Riociguat Impurity 20 (CAS 428854-24-4)
- Riociguat Impurity 18 (CAS 1361569-23-4)
- Riociguat EP Impurity B (CAS 3052969-92-0)
- Riociguat Impurity 41 (CAS CATO-C4X-174941)
- Riociguat Impurity 36 (CAS CATO-C4X-174936)
Recommended Standards
- N,N-dimethyl-4-(((2-methyl-3-oxo-5-(trifluoromethyl)-2,3-dihydro-1H-pyrazol-4-yl)methylene)amino)benzenesulfonamide (CAS 320425-22-7)
- 4,4',4''-Methanetriyltribenzoic acid (CAS 113402-33-8)
- 2-Phenyl-4-((3-(trifluoromethyl)phenyl)thio)pyrimidine-5-carboxylic acid (CAS 477854-57-2)
- N-{4-[(E)-2-(1,3-benzoxazol-2-yl)ethenyl]phenyl}-2,6-difluorobenzamide (CAS 1164548-22-4)
- Nicorandil EP Impurity D (CAS 40055-37-6)
- Teneligliptin impurity 21 (CAS 2459971-79-8)
- Tadalafil Impurity 149 (CAS 2361516-70-1)
- 7-chloro-3-methyl-2,3,4,5-tetrahydro-1,5-benzothiazepin-4-one (CAS 1461708-89-3)
- 4-Methyl-1-(2-methylfuran-3-yl)pentane-1,3-dione (CAS 1339499-25-0)
- 2-Chloro-N-cyclopentyl-5-ethynyl-4-pyrimidinamine (CAS 2445791-51-3)
- tert-Butyl 2-benzylnicotinate (CAS 1159981-88-0)
- 3-(5-Chlorobenzofuran-2-yl)-1H-pyrazole (CAS 852690-99-4)
- Anthracene-9,10-diyldiboronic acid (CAS 251659-87-7)
- semaglutide (CAS 782487-28-9)
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