Riociguat Impurity 18 CAS 1361569-23-4
| CAS No. | 1361569-23-4 |
| Molecular Formula | C20H17FN8O |
| Molecular Weight | 404.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Riociguat Impurity 18 (CAS 1361569-23-4, C20H17FN8O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Riociguat Impurity 18 (C20H17FN8O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Riociguat Impurity 18 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H17FN8O |
| Molecular Weight | 404.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Riociguat Standards
- Riociguat EP Impurity B (CAS 3052969-92-0)
- Riociguat Impurity 41 (CAS CATO-C4X-174941)
- Riociguat Impurity 36 (CAS CATO-C4X-174936)
- Riociguat EP Impurity A (CAS 625115-52-8)
- Riociguat impurity 27 (CAS CATO-C4X-174927)
- Riociguat Impurity 16 (CAS 1361569-18-7)
- Riociguat Impurity 21 (CAS CATO-C4X-174921)
- Riociguat Impurity 11 (CAS CATO-C4X-174911)
Recommended Standards
- Tedizolid Impurity 47 (CAS CATO-C4X-105447)
- Polyester bis-MPA dendron, 4 hydroxyl, 1 acetylene (CAS 1055361-96-0)
- Tedizolid Impurity 39 (CAS 1220910-89-3)
- Nisoldipine Impurity 4 (CAS 106685-70-5)
- Bosutinib Impurity N3 (CAS 17722-32-6)
- Fluticasone Impurity 101 (CAS CATO-C4X-1650101)
- Atropine sulfate EP Impurity G (CAS CATO-C4X-14897)
- tert-Butyl (4-bromo-2-iodophenyl)carbamate (CAS 171513-04-5)
- 6-Bromo-1-methyl-1H-indole (CAS 125872-95-9)
- 2-(2-(4-Chlorophenoxy)-5-chlorophenyl)acetic Acid (CAS 57388-57-5)
- 5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-4-chloro-2-nitro-benzeneacetic Acid (CAS 160384-40-7)
- 2-(3-Methylcyclohexyl)cyclohexan-1-ol (CAS 1342663-72-2)
- 890099-20-4 3-(3,5-Dimethylbenzoyl)phenyl acetate DTXSID30641682 (CAS 890099-20-4)
- Semaglutide impurity 331 (CAS CATO-C4X-2226231)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com