Riociguat impurity 27 CAS CATO-C4X-174927
| CAS No. | CATO-C4X-174927 |
| Molecular Formula | C18H16FN9O |
| Molecular Weight | 393.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Riociguat impurity 27.
Riociguat impurity 27 (CAS CATO-C4X-174927) is a certified pharmaceutical impurity reference standard with the molecular formula C18H16FN9O and a molecular weight of 393.38 g/mol.
Structurally, Riociguat impurity 27 (C18H16FN9O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 393.38 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Riociguat impurity 27 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H16FN9O |
| Molecular Weight | 393.38 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 9 |
Related Riociguat Standards
- Riociguat Impurity 16 (CAS 1361569-18-7)
- Riociguat Impurity 18 (CAS 1361569-23-4)
- Riociguat EP Impurity B (CAS 3052969-92-0)
- Riociguat Impurity 41 (CAS CATO-C4X-174941)
- Riociguat Impurity 36 (CAS CATO-C4X-174936)
- Riociguat EP Impurity A (CAS 625115-52-8)
- Riociguat Impurity 2 (CAS 1361569-10-9)
- Riociguat Impurity 21 (CAS CATO-C4X-174921)
Recommended Standards
- N-(4-Phenoxyphenyl)-3-trifluoromethylbenzenesulfonamide (CAS 292867-24-4)
- 8-((2-(Methoxycarbonyl)phenoxy)carbonyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-4-carboxylic acid (CAS 1008389-50-1)
- 2-((5-(m-Tolyl)-1,3,4-oxadiazol-2-yl)thio)-N-(3-(trifluoromethyl)phenyl)acetamide (CAS 337490-49-0)
- (2S,4R)-1-(tert-Butoxycarbonyl)-4-((4-fluoroisoindoline-2-carbonyl)oxy)pyrrolidine-2-carboxylic acid (CAS 1013925-90-0)
- Hydroxychloroquine Impurity 13 (CAS 2411340-31-1)
- Afoxolaner Impurity 26 (CAS CATO-C4X-313726)
- Ketotifen Impurity 15 (CAS CATO-C4X-204615)
- N1-(5-{[2-nitro-4-(trifluoromethyl)phenyl]thio}-1H-1,2,4-triazol-3-yl)-2,3,3-trichloroacrylamide (CAS 243963-02-2)
- Ceftolozane Impurity 20 (CAS CATO-C4X-240620)
- Ethyl 7-(benzyloxy)-1H-indazole-3-carboxylate (CAS 885278-92-2)
- 3-Ethoxy-2-(4-phenyl-1,3-thiazol-2-yl)prop-2-enenitrile (CAS 709039-11-2)
- trans-4-((2-((1-Benzyl-1H-indol-5-yl)amino)-6-(ethylamino)pyrimidin-4-yl)amino)cyclohexanol (CAS 359886-84-3)
- 3-(3-Fluoro-4-methoxyphenyl)-3-hydroxypropanoic acid (CAS 1484521-11-0)
- Tirzepatide Impurity 17 (CAS CATO-C4X-324017)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com