Ezetimibe Impurity 5 CAS 1374250-07-3
| CAS No. | 1374250-07-3 |
| Molecular Formula | C24H23F2NO2 |
| Molecular Weight | 395.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 395.44 g/mol gives Ezetimibe Impurity 5 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Ezetimibe Impurity 5 (CAS 1374250-07-3) is a certified pharmaceutical impurity reference standard with the molecular formula C24H23F2NO2 and a molecular weight of 395.44 g/mol.
Based on its molecular formula C24H23F2NO2, Ezetimibe Impurity 5 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 395.44 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H23F2NO2 |
| Molecular Weight | 395.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity N38 (CAS 1510820-22-0)
- Ezetimibe Impurity 59 (CAS CATO-C4X-109859)
- Ezetimibe Impurity 1 (CAS 204589-58-2)
- Ezetimibe Impurity 147 (3R,4R) (CAS CATO-C4X-1098147)
- Ezetimibe Desfluoroaniline analog (CAS 302781-98-2)
- Ezetimibe Impurity 22 (CAS 190595-66-5)
- Ezetimibe Impurity 66 (CAS 204589-68-4)
- Ezetimibe Impurity 63 (CAS CATO-C4X-109863)
Recommended Standards
- 6-(Adamantan-1-yl)-3-amino-4-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 488795-66-0)
- Icotinib-d4 (CAS 1567366-82-8)
- 4-(4-Aminoquinazolin-6-yl)-N,N-dimethyl-3-(pyridin-2-yl)-1H-pyrazole-1-sulfonamide (CAS 746669-24-9)
- 3-(4-Methylphenyl)-2-{[3-(trifluoromethyl)phenyl]sulfanyl}quinoline (CAS 339102-64-6)
- Bupropion impurity 70 (CAS 2133460-42-9（free base）)
- Imipenem Impurity 110 (CAS CATO-C4X-1662110)
- Brexpiprazole Impurity 165 (CAS CATO-C4X-1131165)
- 5-(2-Aminoethyl)-1-benzylpyrrolidin-2-one (CAS 1253654-23-7)
- TCO-PEG4-TCO (CAS 2243569-23-3)
- tert-butyl 2-(5-amino-1,3,4-oxadiazol-2-yl)pyrrolidine-1-carboxylate (CAS 887587-93-1)
- (S)-3-(Hydroxymethyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde (CAS 291507-78-3)
- (R)-DTB-SpiroSAP-Ph (CAS 1809609-38-8)
- 4-Methyl-1-(pyridin-2-ylmethyl)-1h-pyrazol-5-amine (CAS 1152524-48-5)
- Tirzepatide Impurity 37 (CAS CATO-C4X-324037)
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