Ezetimibe Impurity 66 CAS 204589-68-4
| CAS No. | 204589-68-4 |
| Molecular Formula | C24H19F2NO2 |
| Molecular Weight | 391.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Ezetimibe Impurity 66 (CAS 204589-68-4) is a certified pharmaceutical impurity reference standard with the molecular formula C24H19F2NO2 and a molecular weight of 391.41 g/mol.
Structurally, Ezetimibe Impurity 66 (C24H19F2NO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 15.0, corresponding to approximately 15 ring(s) or double-bond equivalent(s). With a molecular weight of 391.41 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Ezetimibe Impurity 66 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C24H19F2NO2 |
| Molecular Weight | 391.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Desfluoroaniline analog (CAS 302781-98-2)
- Ezetimibe Impurity 22 (CAS 190595-66-5)
- Ezetimibe Impurity 147 (3R,4R) (CAS CATO-C4X-1098147)
- Ezetimibe Impurity 63 (CAS CATO-C4X-109863)
- Ezetimibe Impurity 1 (CAS 204589-58-2)
- Ezetimibe Impurity 59 (CAS CATO-C4X-109859)
- Ezetimibe Impurity 5 (CAS 1374250-07-3)
- Ezetimibe Impurity N38 (CAS 1510820-22-0)
Recommended Standards
- tert-Butyl 2-(2-(2-(2-(4-amino-2,6-difluorophenoxy)ethoxy)ethoxy)ethoxy)acetate (CAS 2227348-91-4)
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- Propan-2-yl 2-amino-4-(3,4-difluorophenyl)-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carboxylate (CAS 445382-15-0)
- 2,2'-(Azanediylbis(propane-3,1-diyl))bis(isoindoline-1,3-dione) (CAS 102202-87-9)
- Linagliptin Impurity 40 (CAS CATO-C4X-110140)
- Acotiamide Impurity 6 (CAS CATO-C4X-11146)
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- Rilpivirine Keto Impurity (CAS 189956-45-4)
- N,5-Dimethylpyridin-2-amine (CAS 45715-13-7)
- 3-Cyclopropoxy-2-fluorobenzoic acid (CAS 1243400-70-5)
- 2-(3-(3-Fluorophenoxy)propyl)pyrrolidine (CAS 1247490-28-3)
- 2-(Pyridin-2-yl)pyrimidine-4-carboxylic acid (CAS 1094211-77-4)
- 2-Methoxy-5-(pentafluorosulfur)benzyl bromide (CAS 1240257-53-7)
- Atrial Natriuretic Peptide (ANP)(1-28) Alpha (Human, Ovine, Canine) (CAS 91917-63-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com