Ezetimibe Impurity 59 CAS CATO-C4X-109859
| CAS No. | CATO-C4X-109859 |
| Molecular Formula | C23H19F2NO3 |
| Molecular Weight | 395.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ezetimibe Impurity 59.
Ezetimibe Impurity 59 (CAS CATO-C4X-109859) is a certified pharmaceutical impurity reference standard with the molecular formula C23H19F2NO3 and a molecular weight of 395.40 g/mol.
Structurally, Ezetimibe Impurity 59 (C23H19F2NO3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 14.0, corresponding to approximately 14 ring(s) or double-bond equivalent(s). With a molecular weight of 395.40 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H19F2NO3 |
| Molecular Weight | 395.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 5 (CAS 1374250-07-3)
- Ezetimibe Impurity N38 (CAS 1510820-22-0)
- Ezetimibe Impurity 1 (CAS 204589-58-2)
- Ezetimibe Impurity 147 (3R,4R) (CAS CATO-C4X-1098147)
- Ezetimibe Desfluoroaniline analog (CAS 302781-98-2)
- Ezetimibe Impurity 22 (CAS 190595-66-5)
- Ezetimibe Impurity 66 (CAS 204589-68-4)
- Ezetimibe Impurity 63 (CAS CATO-C4X-109863)
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- Vilanterol Impurity 24 Formate (CAS CATO-C4X-193524)
- Belumosudil Impurity 38 (CAS CATO-C4X-298838)
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