Ezetimibe Impurity 147 (3R,4R) CAS CATO-C4X-1098147
| CAS No. | CATO-C4X-1098147 |
| Molecular Formula | C25H22F2O2 |
| Molecular Weight | 392.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ezetimibe Impurity 147 (3R,4R) (C25H22F2O2) is characterized by a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Ezetimibe Impurity 147 (3R,4R) (CAS CATO-C4X-1098147, C25H22F2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C25H22F2O2 |
| Molecular Weight | 392.44 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
Related Ezetimibe Standards
- Ezetimibe Impurity 1 (CAS 204589-58-2)
- Ezetimibe Desfluoroaniline analog (CAS 302781-98-2)
- Ezetimibe Impurity 22 (CAS 190595-66-5)
- Ezetimibe Impurity 66 (CAS 204589-68-4)
- Ezetimibe Impurity 59 (CAS CATO-C4X-109859)
- Ezetimibe Impurity 5 (CAS 1374250-07-3)
- Ezetimibe Impurity N38 (CAS 1510820-22-0)
- Ezetimibe Impurity 63 (CAS CATO-C4X-109863)
Recommended Standards
- H96WTV8SM2 477-33-8 Samidin Crotonic acid, 3-methyl-, 9-ester with 9,10-dihydro-9,10-dihydroxy-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')-dipyran-2-one acetate (+)-Samidin UNII-H96WTV8SM2 (CAS 477-33-8)
- Budesonide Impurity 81 (CAS CATO-C4X-138981)
- Propargyl-PEG7-acid (CAS 2093154-00-6)
- Latamoxef Impurity 20 (CAS CATO-C4X-179820)
- Dexpanthenol Impurity 30 (CAS CATO-C4X-161332)
- Dalilesen Impurity 31 (CAS CATO-C4X-301031)
- Formoterol Impurity 22 HCl (CAS 1049695-95-5)
- 4-Methyl-6-propyl-1,3,5-triazin-2-amine (CAS 1340148-50-6)
- Methyl 5-oxo-2,3,4,5-tetrahydrobenzo[b]oxepine-7-carboxylate (CAS 1116093-90-3)
- 5-(4-Nitrophenoxy)furan-2-carbaldehyde (CAS 62427-28-5)
- 5-(3-Ethyl-1-methyl-1H-pyrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine (CAS 622403-68-3)
- 2-(6-Bromopyridin-3-yl)pyrrolidine-1-carbaldehyde (CAS 1352499-94-5)
- 4-Amino-3-bromo-5-(difluoromethyl)picolinaldehyde (CAS 1804450-18-7)
- Tetrapeptide-3 (CAS 827306-97-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com