Ezetimibe Impurity 1 CAS 204589-58-2
| CAS No. | 204589-58-2 |
| Molecular Formula | C24H21F2NO2 |
| Molecular Weight | 393.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 393.43 g/mol gives Ezetimibe Impurity 1 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Ezetimibe Impurity 1 (CAS 204589-58-2), a pharmacopoeial impurity reference standard (molecular formula C24H21F2NO2, MW 393.43 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C24H21F2NO2, Ezetimibe Impurity 1 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 393.43 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ezetimibe Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H21F2NO2 |
| Molecular Weight | 393.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2015 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Ezetimibe Standards
- Ezetimibe Impurity 147 (3R,4R) (CAS CATO-C4X-1098147)
- Ezetimibe Impurity 59 (CAS CATO-C4X-109859)
- Ezetimibe Desfluoroaniline analog (CAS 302781-98-2)
- Ezetimibe Impurity 22 (CAS 190595-66-5)
- Ezetimibe Impurity 5 (CAS 1374250-07-3)
- Ezetimibe Impurity N38 (CAS 1510820-22-0)
- Ezetimibe Impurity 66 (CAS 204589-68-4)
- Ezetimibe Impurity 63 (CAS CATO-C4X-109863)
Recommended Standards
- Ticagrelor Impurity 142 (CAS 866551-95-3)
- Metaraminol Impurity 65 (CAS 31301-86-7)
- Z-Gly-Leu-Ala-OH (C-3260.0250) (CAS 24960-20-1)
- Daprodustat impurity 5 (CAS CATO-C4X-24075)
- Ruxolitinib Impurity 16 (CAS 28791-95-9)
- Estriol impurity 25 (CAS 55105-93-6)
- Flupirtine Impurity 2 (CAS 33400-49-6)
- 2-Bromo-3,5-dichloro-1-fluoro-4-methoxybenzene (CAS 2140305-64-0)
- (2R)-3,3-dimethylpyrrolidine-2-carboxylic acid (CAS 1027802-81-8)
- 3-(Thiophen-2-yl)-5-(1-(thiophen-2-ylsulfonyl)piperidin-4-yl)-1,2,4-oxadiazole (CAS 946301-03-7)
- (2R,6S)-4-tert-butyl 2-methyl 6-(hydroxymethyl)morpholine-2,4-dicarboxylate (CAS 1951425-25-4)
- 2-Chloropyrido[2,3-d]pyrimidin-4(3H)-one hydrochloride (CAS 126728-21-0)
- 4-(Pentylamino)butanamide (CAS 90068-18-1)
- Peptide Impurity 12 (CAS CATO-CPTD788812)
Why CATO?
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