Letrozole Impurity 29 CAS 612-13-5
| CAS No. | 612-13-5 |
| Molecular Formula | C8H6ClN |
| Molecular Weight | 151.59 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 151.59 g/mol gives Letrozole Impurity 29 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Letrozole Impurity 29 (CAS 612-13-5, C8H6ClN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution, Letrozole Impurity 29 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 151.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Letrozole Impurity 29 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6ClN |
| Molecular Weight | 151.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Letrozole Standards
- Letrozole Impurity 30 (CAS 64407-07-4)
- Letrozole Impurity 38 (CAS 874-86-2)
- Letrozole Impurity N2 (CAS 84545-14-2)
- Letrozole Impurity 17 (CAS 112809-27-5)
- Letrozole Impurity 22 (CAS 876728-37-9)
- Letrozole Impurity 23 (CAS 876316-41-5)
- Letrozole Impurity 4 (CAS 112809-25-3)
- Letrozole Impurity 15 (CAS 74231-65-5)
Recommended Standards
- Loratadine Impurity 69 (CAS 1529-41-5)
- Linezolid Impurity 40 (CAS 224323-47-1)
- Linezolid Impurity 77 (CAS 3920-11-4)
- Pyrimethamine EP Impurity C (CAS 140-53-4)
- Fluticasone Impurity 67 (CAS CATO-C4X-165067)
- Vildagliptin Impurity 64 (CAS 105-48-6)
- Dapsone EP Impurity E (CAS 7146-68-1)
- Aprotinin (CAS 9087-70-1)
- 4-Methoxy-6-methyl-2-(piperazin-1-yl)pyrimidine hydrochloride (CAS 1779124-79-6)
- 2-(4-Bromophenyl)-2-cyclopropylpropanenitrile (CAS 1360551-88-7)
- n-(3,4-Dichlorobenzyl)ethanamine (CAS 68621-16-9)
- 2-(2,6-Dimethylphenoxy)ethane-1-sulfonyl chloride (CAS 1018548-31-6)
- 4-Methyl-5-oxotetrahydrofuran-3-carboxylic acid (CAS 89533-85-7)
- Palmitoyl Tripeptide-1 HCl (CAS 2757690-14-3)
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