Remimazolam Impurity 6 CAS 1449295-47-9
| CAS No. | 1449295-47-9 |
| Molecular Formula | C18H16BrN3O3 |
| Molecular Weight | 402.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Remimazolam Impurity 6 (CAS 1449295-47-9) is a certified pharmaceutical impurity reference standard with the molecular formula C18H16BrN3O3 and a molecular weight of 402.24 g/mol.
Remimazolam Impurity 6 (C18H16BrN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Remimazolam Impurity 6 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H16BrN3O3 |
| Molecular Weight | 402.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 3 |
Related Remimazolam Standards
- Remimazolam Impurity 1 (CAS 1275616-59-5)
- Remimazolam Impurity 4 (CAS 308242-23-1)
- Remimazolam Impurity 1 (CAS CATO-C4X-28231)
- Remimazolam Impurity 7 (CAS CATO-C4X-28237)
- Remimazolam Impurity 5 (CAS 1276185-51-3)
- Remimazolam Impurity 2 (CAS 960305-91-3)
- Remimazolam Impurity 17 (CAS CATO-C4X-282317)
- Remimazolam Impurity 12 (CAS 308243-65-4)
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