Remimazolam Impurity 1 CAS CATO-C4X-28231
| CAS No. | CATO-C4X-28231 |
| Molecular Formula | C18H17BrN4O2 |
| Molecular Weight | 401.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Remimazolam Impurity 1 (C18H17BrN4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Remimazolam Impurity 1 (CAS CATO-C4X-28231), a pharmacopoeial impurity reference standard (molecular formula C18H17BrN4O2, MW 401.26 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H17BrN4O2 |
| Molecular Weight | 401.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 4 |
Related Remimazolam Standards
- Remimazolam Impurity 1 (CAS 1275616-59-5)
- Remimazolam Impurity 4 (CAS 308242-23-1)
- Remimazolam Impurity 6 (CAS 1449295-47-9)
- Remimazolam Impurity 7 (CAS CATO-C4X-28237)
- Remimazolam Impurity 5 (CAS 1276185-51-3)
- Remimazolam Impurity 2 (CAS 960305-91-3)
- Remimazolam Impurity 17 (CAS CATO-C4X-282317)
- Remimazolam Impurity 12 (CAS 308243-65-4)
Recommended Standards
- Eltrombopag Impurity 134 (CAS CATO-C4X-1198134)
- GSK-626616 (CAS 1025821-33-3)
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- Vonoprazan Impurity 197 (CAS CATO-C4X-1020197)
- Vortioxetine Impurity 82 (CAS 583-55-1)
- Ilaprazole Impurity 227 (CAS CATO-C4X-1130227)
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- 3-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridine (CAS 1573171-45-5)
- Semaglutide impurity 274 (CAS CATO-C4X-2226274)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com