Roflumilast Impurity 32 CAS 1454574-39-0
| CAS No. | 1454574-39-0 |
| Molecular Formula | C17H14Cl2F2N2O2 |
| Molecular Weight | 387.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Roflumilast Impurity 32 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Roflumilast Impurity 32 (CAS 1454574-39-0), a pharmacopoeial impurity reference standard (molecular formula C17H14Cl2F2N2O2, MW 387.21 g/mol) used for the identification and quantification of trace impurities in APIs.
Roflumilast Impurity 32 (C17H14Cl2F2N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C17H14Cl2F2N2O2 |
| Molecular Weight | 387.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | ＞95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Roflumilast Standards
- Roflumilast Impurity 4 (CAS 162401-30-1)
- Roflumilast (CAS 162401-32-3)
- Roflumilast Impurity 1 (CAS 162401-43-6)
- Roflumilast Impurity 29 (CAS 2368178-28-1)
- Roflumilast Impurity 53 (CAS 2204417-23-0)
- Roflumilast Impurity 7 (CAS 1391053-75-0)
- Roflumilast-d3 (CAS 1189992-00-4)
- Roflumilast -D4 (CAS 1398065-69-4)
Recommended Standards
- Ethyl 1-(3-iodobenzoyl)piperidine-3-carboxylate (CAS 349442-23-5)
- 3-(1-(4-Bromophenyl)-3-oxobutyl)-4-hydroxy-2H-chromen-2-one (CAS 101894-60-4)
- 3,5-Dichloro-2-{[(2-Fluorobenzoyl)Carbamothioyl]Amino}Benzoic Acid (CAS 535976-72-8)
- 1-((4-Bromo-3-(trifluoromethyl)phenyl)sulfonyl)-4-methylpiperazine (CAS 486422-42-8)
- Osimertinib Impurity 73 (CAS CATO-C4X-204573)
- Avibactam Impurity 78 (CAS CATO-C4X-134878)
- Biapenem impurity 12 (CAS CATO-C4X-227312)
- Dioctyl terephthalate (CAS 4654-26-6)
- 4,4'-Bis((E)-4-methoxystyryl)-2,2'-bipyridine (CAS 166827-53-8)
- Avocadene (CAS 24607-08-7)
- 3-(Difluoromethyl)-4-iodo-1H-pyrazole (CAS 1354704-07-6)
- 6-(4-Benzylpiperidin-1-yl)pyridazine-3-carboxylic acid (CAS 1448028-09-8)
- 9,10-Dihydroxy-5-methoxy-2H-pyrano[2,3,4-kl]xanthen-2-one (CAS 89783-74-4)
- [2-31]-Semaglutide C (x TFA Salt) (CAS CATO-C4X-2226118)
Why CATO?
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