Empagliflozin Impurity 95 CAS 1459754-40-5
| CAS No. | 1459754-40-5 |
| Molecular Formula | C13H8ClIO2 |
| Molecular Weight | 358.56 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Empagliflozin Impurity 95 (CAS 1459754-40-5) is a certified pharmaceutical impurity reference standard with the molecular formula C13H8ClIO2 and a molecular weight of 358.56 g/mol.
Structurally, Empagliflozin Impurity 95 (C13H8ClIO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine/iodine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 358.56 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Empagliflozin Impurity 95 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H8ClIO2 |
| Molecular Weight | 358.56 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 283 (CAS 1713015-56-5)
- Empagliflozin impurity 245 (CAS CATO-C4X-1065245)
- Empagliflozin Impurity 104 (CAS 76049-49-5)
- Empagliflozin Impurity 132 (CAS 2452301-23-2)
- Empagliflozin impurity 247 (CAS CATO-C4X-1065247)
- Empagliflozin impurity 248 (CAS 143128-40-9)
- Empagliflozin impurity 252 (CAS CATO-C4X-1065252)
- Empagliflozin impurity 22 (CAS CATO-C4X-1065322)
Recommended Standards
- Ethyl 4(Z),7(Z),10(Z),13(Z),16(Z)-docosapentaenoate (CAS 142828-42-0)
- 2-Monostearin (CAS 621-61-4)
- Monostearin (CAS 31566-31-1)
- (9Z,12Z,15Z,18Z,21Z)-tetracosa-9,12,15,18,21-pentaenoic acid (CAS 68378-48-3)
- Epinephrine Impurity 132 (CAS CATO-C4X-1849132)
- Roxadustat Impurity 16 (CAS CATO-C4X-221316)
- Quetiapine Impurity N3 (CAS 102893-57-2)
- Nitrofurantoin sodium (CAS 54-87-5)
- 2,3-Dimethylglutaric Acid (CAS 17179-91-8)
- 5-(Hydroxymethyl)-3-methoxy-1-methyl-1H-pyrazole (CAS 865138-51-8)
- 2H-1,3-Benzoxazin-2-one, 3,4-dihydro-3-(4-pyridinyl)- (CAS 1448061-71-9)
- 4-ethynyl-1-azabicyclo[2.2.2]octane (CAS 52547-86-1)
- 108704-93-4 2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetyl chloride F1908-0053 (CAS 108704-93-4)
- [pGlu] Semaglutide (CAS CATO-C4X-2226288)
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