Empagliflozin impurity 252 CAS CATO-C4X-1065252
| CAS No. | CATO-C4X-1065252 |
| Molecular Formula | C13H7ClFIO |
| Molecular Weight | 360.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Empagliflozin impurity 252 (C13H7ClFIO) contains a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 360.55 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Empagliflozin impurity 252 (CAS CATO-C4X-1065252) is a certified pharmaceutical impurity reference standard with the molecular formula C13H7ClFIO and a molecular weight of 360.55 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H7ClFIO |
| Molecular Weight | 360.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 104 (CAS 76049-49-5)
- Empagliflozin Impurity 132 (CAS 2452301-23-2)
- Empagliflozin impurity 247 (CAS CATO-C4X-1065247)
- Empagliflozin impurity 248 (CAS 143128-40-9)
- Empagliflozin impurity 22 (CAS CATO-C4X-1065322)
- Empagliflozin Impurity 45 (CAS CATO-C4X-106545)
- Empagliflozin Impurity 91 (CAS 915095-86-2)
- Empagliflozin Impurity 145 (CAS CATO-C4X-1065145)
Recommended Standards
- 2-Acetamido-6-iodopyridine-4-sulfonyl chloride (CAS 1393531-40-2)
- 4-Chloro-3-fluoro-4-iodobenzophenone (CAS 951890-71-4)
- 4-Acetamido-6-iodopyridine-2-sulfonyl chloride (CAS 1393582-75-6)
- 4-Chloro-3-fluoro-2-iodobenzophenone (CAS 951890-65-6)
- Eltrombopag Impurity 75 (CAS CATO-C4X-119875)
- Beclometasone Dipropionate Monohydrate EP Impurity C (CAS CATO-C4X-14743)
- Trimetazidine EP Impurity G (CAS 110-85-0)
- Boc-Thr(Leu-Fmoc)-OH (CAS 944283-26-5)
- Avibactam Impurity 61 (CAS CATO-C4X-134861)
- Methyl (R)-3-amino-3-(2-chlorophenyl)propanoate (CAS 1228547-80-5)
- 6-beta-Hydroxytestosterone (CAS 62-99-7)
- 5-(4-Cyclopropyl-4H-1,2,4-triazol-3-yl)pyridin-2-amine (CAS 1340286-52-3)
- 2-(2-Bromo-5-fluorophenoxy)-3-(dimethylamino)acrylonitrile (CAS 1620478-72-9)
- Peptide 442 (CAS CATO-CPTD788442)
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