Empagliflozin impurity 248 CAS 143128-40-9
| CAS No. | 143128-40-9 |
| Molecular Formula | C13H7ClFIO |
| Molecular Weight | 360.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Empagliflozin impurity 248 (CAS 143128-40-9, C13H7ClFIO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C13H7ClFIO, Empagliflozin impurity 248 contains a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 360.55 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H7ClFIO |
| Molecular Weight | 360.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | F/Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 104 (CAS 76049-49-5)
- Empagliflozin Impurity 132 (CAS 2452301-23-2)
- Empagliflozin impurity 247 (CAS CATO-C4X-1065247)
- Empagliflozin impurity 252 (CAS CATO-C4X-1065252)
- Empagliflozin impurity 22 (CAS CATO-C4X-1065322)
- Empagliflozin Impurity 45 (CAS CATO-C4X-106545)
- Empagliflozin Impurity 91 (CAS 915095-86-2)
- Empagliflozin Impurity 145 (CAS CATO-C4X-1065145)
Recommended Standards
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- 3-Chloro-5-fluoro-2-iodobenzophenone (CAS 951890-42-9)
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- 3-Bromo-2,4-difluoro-6-iodobenzoic acid (CAS 1160573-53-4)
- Ethyl 5-(4-chlorophenyl)thiophene-2-carboxylate (CAS 19282-40-7)
- 3-Bromo-1-fluoro-2-iodonaphthalene (CAS 874907-48-9)
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