Empagliflozin impurity 22 CAS CATO-C4X-1065322
| CAS No. | CATO-C4X-1065322 |
| Molecular Formula | C13H7ClFIO |
| Molecular Weight | 360.55 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Empagliflozin impurity 22 is closely related to a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Empagliflozin impurity 22 (CAS CATO-C4X-1065322) is a certified pharmaceutical impurity reference standard with the molecular formula C13H7ClFIO and a molecular weight of 360.55 g/mol.
Empagliflozin impurity 22 (C13H7ClFIO) contains a hydroxyl group, an ether linkage, fluorine/chlorine/iodine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Empagliflozin impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H7ClFIO |
| Molecular Weight | 360.55 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl/I-containing |
Related Empagliflozin Standards
- Empagliflozin Impurity 104 (CAS 76049-49-5)
- Empagliflozin Impurity 132 (CAS 2452301-23-2)
- Empagliflozin impurity 247 (CAS CATO-C4X-1065247)
- Empagliflozin impurity 248 (CAS 143128-40-9)
- Empagliflozin impurity 252 (CAS CATO-C4X-1065252)
- Empagliflozin Impurity 45 (CAS CATO-C4X-106545)
- Empagliflozin Impurity 91 (CAS 915095-86-2)
- Empagliflozin Impurity 145 (CAS CATO-C4X-1065145)
Recommended Standards
- 2-Acetamido-6-iodopyridine-4-sulfonyl chloride (CAS 1393531-40-2)
- 4-Acetamido-6-iodopyridine-2-sulfonyl chloride (CAS 1393582-75-6)
- 6-Acetamido-4-iodopyridine-2-sulfonyl chloride (CAS 1393583-26-0)
- 4-Chloro-3-fluoro-4-iodobenzophenone (CAS 951890-71-4)
- Levocetirizine Impurity 55 (CAS 705289-61-8)
- Tepotinib impurity 8 (CAS CATO-C4X-33748)
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- 4-(4-Hydroxy-3-methoxyphenyl)butanoic acid (CAS 14563-39-4)
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- (Leu31,Pro34)-Peptide YY (human) trifluoroacetate salt (CAS 179986-95-9)
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