Sitagliptin Impurity 147 CAS 1481965-39-2
| CAS No. | 1481965-39-2 |
| Molecular Formula | C7H7F3N4O |
| Molecular Weight | 220.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 220.15 g/mol gives Sitagliptin Impurity 147 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Sitagliptin Impurity 147 (CAS 1481965-39-2) is a certified pharmaceutical impurity reference standard with the molecular formula C7H7F3N4O and a molecular weight of 220.15 g/mol.
Based on its molecular formula C7H7F3N4O, Sitagliptin Impurity 147 contains an amide group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 220.15 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H7F3N4O |
| Molecular Weight | 220.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Sitagliptin Standards
- Sitagliptin Impurity 118 (CAS 1261633-32-2)
- Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) (CAS 2892260-32-9)
- Sitagliptin Impurity 58 (CAS 667-35-6)
- Sitagliptin Impurity 166 (CAS 2226094-64-8)
- Sitagliptin Impurity 167 (CAS 1840966-95-1)
- Sitagliptin Impurity 109 (CAS 936630-56-7)
- Sitagliptin Impurity 78-d4 (CAS 2892260-32-9 (unlabelled))
- Sitagliptin Impurity 127 (CAS CATO-C4X-1144127)
Recommended Standards
- 3-Bromo-2,4,6-trimethyl-phenylamine 3-Bromo-2,4,6-trimethylaniline 82842-52-2 A19790 (CAS 82842-52-2)
- Gatifloxacin Impurity 22 (CAS 136897-64-8)
- 2-(Trifluoromethoxy)phenylacetic acid 2-trifluoromethoxyphenyl acetic acid (2-trifluoromethoxy-phenyl)-acetic acid 220239-67-8 (CAS 220239-67-8)
- Travoprost Impurity 6 (CAS 349-82-6)
- Irbesartan Impurity 7 (CAS 138401-24-8)
- Teprenone Impurity 4 (CAS 1117-51-7)
- Baloxavir impurity C868 (CAS 1985607-65-5)
- Nemonoxacin Impurity 100 (CAS CATO-C4X-3128100)
- 4-[Chloro(difluoro)methoxy]-1-fluoro-2-nitro-benzene (CAS 146780-22-5)
- 2,4-Dibromo-1-(2-bromoethyl)benzene (CAS 59216-17-0)
- Di-(O-tert-Butyl-dimethylsilyl) 3,5-Dihydroxycurcumin (CAS 1795128-69-6)
- [4-(hydroxymethyl)-2,5-diiodophenyl]methanol (CAS 915706-87-5)
- Dimethyl 5-(methoxymethyl)pyridine-2,3-dicarboxylate (CAS 139123-56-1)
- Semaglutide impurity 78 (CAS CATO-C4X-222678)
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