Sitagliptin Impurity 118 CAS 1261633-32-2
| CAS No. | 1261633-32-2 |
| Molecular Formula | C9H7ClF2O2 |
| Molecular Weight | 220.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Sitagliptin Impurity 118 (CAS 1261633-32-2) is a certified pharmaceutical impurity reference standard with the molecular formula C9H7ClF2O2 and a molecular weight of 220.60 g/mol.
The molecular framework of Sitagliptin Impurity 118 (C9H7ClF2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Sitagliptin Impurity 118 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7ClF2O2 |
| Molecular Weight | 220.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Sitagliptin Standards
- Sitagliptin Impurity 147 (CAS 1481965-39-2)
- Sitagliptin Impurity 78 (Nitroso-STG-19) (NTTP) (CAS 2892260-32-9)
- Sitagliptin Impurity 58 (CAS 667-35-6)
- Sitagliptin Impurity 166 (CAS 2226094-64-8)
- Sitagliptin Impurity 167 (CAS 1840966-95-1)
- Sitagliptin Impurity 78-d4 (CAS 2892260-32-9 (unlabelled))
- Sitagliptin Impurity 109 (CAS 936630-56-7)
- Sitagliptin Impurity 127 (CAS CATO-C4X-1144127)
Recommended Standards
- Ethyl 4-chloro-2,6-difluorobenzoate (CAS 773139-38-1)
- Tegoprazan Impurity 10 (CAS CATO-C4X-229710)
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- Tegoprazan Impurity 130 (CAS CATO-C4X-2297130)
- Trazodone impurity 76 (CAS CATO-C4X-177276)
- Rupatadine Impurity 36 (CAS 169253-15-0)
- Cefaclor EP Impurity E (CAS 188915-50-6)
- Methyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-methyl-L-serinate (CAS 159610-95-4)
- Empagliflozin Impurity 110 (CAS CATO-C4X-1065110)
- 2-[bromo(phenyl)methyl]pyridine (CAS 1073477-82-3)
- 1,4-Dioxaspiro[4.5]decane-2-carbaldehyde (CAS 92822-62-3)
- 2,4-Dichlorophenyl (E)-3-(dimethylamino)acrylate (CAS 338395-30-5)
- Potassium (3-(benzyloxy)prop-1-en-2-yl)trifluoroborate (CAS 1376707-99-1)
- Peptide Impurity 40 (CAS CATO-CPTD788840)
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