Paclitaxel EP Impurity K CAS 148930-55-6
| CAS No. | 148930-55-6 |
| Molecular Formula | C53H65NO14Si |
| Molecular Weight | 968.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO supplies Paclitaxel EP Impurity K (CAS 148930-55-6), a pharmacopoeial impurity reference standard (molecular formula C53H65NO14Si, MW 968.17 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Paclitaxel EP Impurity K (C53H65NO14Si) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 22.0, corresponding to approximately 22 ring(s) or double-bond equivalent(s). With a molecular weight of 968.17 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C53H65NO14Si |
| Molecular Weight | 968.17 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 22.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Nitrogen Atoms | 1 |
Related Paclitaxel Standards
- Paclitaxel Ceribate (CAS 186040-50-6)
- Paclitaxel EP Impurity J (CAS 2757197-26-3)
- Paclitaxel EP Impurity L (CAS 92950-39-5)
- Paclitaxel Impurity 57 (CAS 1053697-17-8)
- Paclitaxel EP Impurity O (CAS 219783-77-4)
- Paclitaxel EP Impurity M (CAS 932042-85-8)
- Paclitaxel EP Impurity P (CAS 173101-56-9)
- Paclitaxel EP Impurity F (CAS 153083-53-5)
Recommended Standards
- 2'-O-(tert-Butyldimethylsilyl) Paclitaxel (CAS 114655-02-6)
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