Hydrocortisone EP Impurity H CAS CATO-C4X-14018
| CAS No. | CATO-C4X-14018 |
| Molecular Formula | C21H30O6 |
| Molecular Weight | 378.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Hydrocortisone EP Impurity H.
CATO supplies Hydrocortisone EP Impurity H (CAS CATO-C4X-14018), a pharmacopoeial impurity reference standard (molecular formula C21H30O6, MW 378.46 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Hydrocortisone EP Impurity H (C21H30O6) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H30O6 |
| Molecular Weight | 378.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
Related Hydrocortisone Standards
- Hydrocortisone EP Impurity O (CAS 154032-37-8)
- Hydrocortisone Impurity 21 (CAS 68473-77-8)
- Hydrocortisone EP Impurity D (CAS 53-35-0)
- Hydrocortisone EP Impurity I (CAS 103795-84-2)
- Hydrocortisone 21-Carboxylic Acid (CAS 57172-48-2)
- Hydrocortisone Impurity 65 (CAS CATO-C4X-140165)
- Hydrocortisone Impurity 71 (CAS 37413-94-8)
- Hydrocortisone EP Impurity E (CAS 7753-60-8)
Recommended Standards
- Lotilaner Impurity 15 (CAS CATO-C4X-325615)
- Neotame (CAS 165450-17-9)
- Budesonide Impurity 34 (CAS 1171-81-9)
- Z-Leu-Leu-OH (CAS 7801-71-0)
- Dapagliflozin Impurity 3 (CAS CATO-C4X-11383)
- Mianserin Impurity 94 (CAS CATO-C4X-136994)
- Ticagrelor EP Impurity A (CAS 1251765-07-7)
- 4-(Thiophen-2-yl)-1H-pyrazole (CAS 76153-66-7)
- 2,6-Dibromo-4-(difluoromethyl)pyridine-3-sulfonamide (CAS 1806891-17-7)
- 3,3,3-Trifluoropropyl 2,5-dimethylphenyl sulfide (CAS 1779124-28-5)
- 1-(4-((1H-pyrazol-1-yl)methyl)phenyl)-N-methylmethanamine (CAS 892502-08-8)
- Methyl 4,4-dimethyl-1,2,3,4-tetrahydroisoquinoline-6-carboxylate (CAS 1203682-73-8)
- 5-Methyl-4-nitro-1H-pyrrolo[2,3-b]pyridine (CAS 1638759-44-0)
- Semaglutide impurity 107 (CAS CATO-C4X-2226107)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com