Hydrocortisone EP Impurity E CAS 7753-60-8
| CAS No. | 7753-60-8 |
| Molecular Formula | C23H30O5 |
| Molecular Weight | 386.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Hydrocortisone EP Impurity E (C23H30O5) contains a flavonoid core, a hydroxyl group, an ether linkage. The carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Hydrocortisone EP Impurity E (CAS 7753-60-8, C23H30O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Hydrocortisone EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H30O5 |
| Molecular Weight | 386.48 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1959 |
Related Hydrocortisone Standards
- Hydrocortisone EP Impurity K (CAS 640-87-9)
- Hydrocortisone Impurity 64 (CAS 96391-56-9)
- Hydrocortisone EP Impurity O (CAS 154032-37-8)
- Hydrocortisone Impurity 21 (CAS 68473-77-8)
- Hydrocortisone EP Impurity D (CAS 53-35-0)
- Hydrocortisone EP Impurity H (CAS CATO-C4X-14018)
- Hydrocortisone EP Impurity I (CAS 103795-84-2)
- Hydrocortisone 21-Carboxylic Acid (CAS 57172-48-2)
Recommended Standards
- Euglobal Ia2 (CAS 77794-63-9)
- O1,O4-ditert-butyl O2-ethyl 5,5-dimethylpiperazine-1,2,4-tricarboxylate (CAS 363192-03-4)
- Euglobal Ia1 (CAS 77844-93-0)
- Spironolactone Impurity 11 (CAS 2537956-65-1)
- Doxorubicin Impurity 24 (CAS CATO-C4X-203324)
- Tacrolimus impurity 68 (CAS 1262804-11-4)
- Vinpocetine EP Impurity B (CAS 4880-92-6)
- 3-Amino-2-(2-(diethylamino)thiazol-5-yl)-1,1,1-trifluoropropan-2-ol (CAS 1235439-98-1)
- Saxagliptin Impurity 36 Mesylate (CAS 1564266-74-5)
- 2-Chloro-N-(m-tolyl)-N-(4-(p-tolyl)thiazol-2-yl)acetamide (CAS 730951-08-3)
- N-{[3-(4-methoxyphenyl)-1,2-oxazol-5-yl]methyl}acetamide (CAS 551921-31-4)
- 6,8-Dimethyl-2-(o-tolyl)quinoline-4-carboxylic acid (CAS 725687-84-3)
- 1-{1-phenyl-1h-pyrazolo[3,4-d]pyrimidin-4-yl}piperidine-4-carboxylic acid (CAS 932162-77-1)
- Angiotensin III Antipeptide (CAS 133605-55-7)
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