Tolvaptan Impurity 116 CAS 1580889-35-5
| CAS No. | 1580889-35-5 |
| Molecular Formula | C26H24ClN3O3 |
| Molecular Weight | 461.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Tolvaptan Impurity 116 (CAS 1580889-35-5, C26H24ClN3O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Tolvaptan Impurity 116 (C26H24ClN3O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO manufactures Tolvaptan Impurity 116 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C26H24ClN3O3 |
| Molecular Weight | 461.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tolvaptan Standards
- Tolvaptan Impurity 126 (CAS CATO-C4X-1955126)
- Tolvaptan Impurity 46 (CAS 2468638-31-3)
- Tolvaptan Impurity 47 (CAS 150683-52-6)
- Tolvaptan Impurity 65 (CAS CATO-C4X-195565)
- Tolvaptan Impurity 96 (CAS 1587638-01-4)
- Tolvaptan Impurity 51 (CAS CATO-C4X-195551)
- Tolvaptan-d7 (CAS 1246818-18-7)
- Tolvaptan Impurity 108 (CAS CATO-C4X-1955108)
Recommended Standards
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- (2E)-3-(4-chlorophenyl)-2-{5-[(2E)-3-(dimethylamino)prop-2-enoyl]thiophen-2-yl}prop-2-enenitrile 338795-15-6 6J-035 (CAS 338795-15-6)
- 114912-35-5 Ciwujianoside D1 Olean-12-en-28-oic acid, 3-(alpha-L-arabinopyranosyloxy)-, O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-6-O-acetyl-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester, (3beta)- 3-(alpha-L-Arabinopyranosyloxy)-olean-12-en-28-oic acid O-6-deoxy-alpha-L-mannopyranosyl-(1-4)-O-6-O-acetyl-beta-D-glucopyranosyl-(1-6)-beta-D-glucopyranosyl ester (CAS 114912-35-5)
- Semaglutide impurity 23 (CAS CATO-C4X-222623)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com