Resmetirom Impurity 8 CAS 1581304-46-2
| CAS No. | 1581304-46-2 |
| Molecular Formula | C10H6Cl3N3O |
| Molecular Weight | 290.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Resmetirom Impurity 8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Resmetirom Impurity 8 (CAS 1581304-46-2, C10H6Cl3N3O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C10H6Cl3N3O, Resmetirom Impurity 8 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 290.53 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C10H6Cl3N3O |
| Molecular Weight | 290.53 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom Impurity 43 (CAS CATO-C4X-291243)
- Resmetirom impurity 121 (CAS CATO-C4X-2912121)
- Resmetirom Impurity 62 (CAS CATO-C4X-291262)
- Resmetirom impurity 66 (CAS CATO-C4X-291266)
- Resmetirom impurity 67 (CAS CATO-C4X-291267)
- Resmetirom Impurity 9 (CAS CATO-C4X-29129)
- Resmetirom Impurity 22 (CAS 125001-18-5)
- Resmetirom impurity 124 (CAS CATO-C4X-2912124)
Recommended Standards
- Anagrelide impurity 25 (CAS 1092352-99-2)
- 5-(bromomethyl)-3-(4-chlorophenyl)-1,3-oxazolidin-2-one (CAS 104392-63-4)
- Cloxacillin Impurity 30 (CAS 1189758-12-0)
- 6-bromo-4-(2-chloroethyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS 1094298-71-1)
- Brexpiprazole Impurity 165 (CAS CATO-C4X-1131165)
- Midazolam Impurity 31 (CAS CATO-C4X-150931)
- Gaspofungin Impurity F (CAS CATO-C4X-157521)
- 3-(4-Chloro-3,5-dimethyl-1h-pyrazol-1-yl)propanehydrazide (CAS 942877-64-7)
- n-(Cyclohexylmethyl)-2-methylpropan-2-amine (CAS 65055-37-0)
- 3-(Diethylamino)propanenitrile (CAS 5351-04-2)
- (3H-Imidazo[4,5-b]pyridin-5-yl)methanol (CAS 1352911-89-7)
- 2-Fluoro-4-(1H-1,2,4-triazol-1-yl)benzaldehyde (CAS 1216592-60-7)
- (2-Bromo-5-methoxyphenyl)(4-chlorophenyl)methanone (CAS 746651-89-8)
- Tetrapeptide-30/Tegopep (CAS 1036207-61-0)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com