Resmetirom impurity 121 CAS CATO-C4X-2912121
| CAS No. | CATO-C4X-2912121 |
| Molecular Formula | C11H9Cl2N3O2 |
| Molecular Weight | 286.11 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Resmetirom impurity 121 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Resmetirom impurity 121 (CAS CATO-C4X-2912121, C11H9Cl2N3O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Resmetirom impurity 121 (C11H9Cl2N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C11H9Cl2N3O2 |
| Molecular Weight | 286.11 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom Impurity 8 (CAS 1581304-46-2)
- Resmetirom impurity 76 (CAS CATO-C4X-291276)
- Resmetirom impurity 80 (CAS CATO-C4X-291280)
- Resmetirom Impurity 43 (CAS CATO-C4X-291243)
- Resmetirom impurity 94 (CAS CATO-C4X-291294)
- Resmetirom Impurity 62 (CAS CATO-C4X-291262)
- Resmetirom impurity 66 (CAS CATO-C4X-291266)
- Resmetirom impurity 67 (CAS CATO-C4X-291267)
Recommended Standards
- Furosemide Impurity 50 (CAS CATO-C4X-140250)
- Vinclozolin (CAS 50471-44-8)
- Lenvatinib Impurity 108 (CAS CATO-C4X-1140108)
- Ethyl 8-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine-2-carboxylate (CAS 1021859-84-6)
- Ruxolitinib Impurity 28 (CAS CATO-C4X-205828)
- Ramelteon Impurity 14 (CAS 326793-94-6)
- Semaglutide impurity 68 (CAS CATO-C4X-222668)
- 3-bromo-6-fluoro-1H-pyrrolo[2,3-b]pyridine (CAS 1190315-22-0)
- Ethyl 2-(methylthio)benzoate (CAS 1442-00-8)
- 4-(2-Chloroacetamido)benzoic acid (CAS 4596-39-8)
- 3-[(2-aminophenyl)sulfanyl]-2-methylpropanenitrile (CAS 37845-63-9)
- Ethyl 4-(3-bromo-4-fluorophenyl)-7-(3,4-dimethoxyphenyl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate (CAS 333308-94-4)
- (1-(5-Chloro-1H-pyrrolo[2,3-b]pyridin-1-yl)cyclopentyl)methanol (CAS 2173992-11-3)
- Semaglutide impound 212 (CAS CATO-C4X-2226212)
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