Resmetirom Impurity 9 CAS CATO-C4X-29129
| CAS No. | CATO-C4X-29129 |
| Molecular Formula | C13H13Cl2N3O |
| Molecular Weight | 298.17 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 298.17 g/mol gives Resmetirom Impurity 9 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Resmetirom Impurity 9 (CAS CATO-C4X-29129), a pharmacopoeial impurity reference standard (molecular formula C13H13Cl2N3O, MW 298.17 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Resmetirom Impurity 9 (C13H13Cl2N3O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Resmetirom Impurity 9 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H13Cl2N3O |
| Molecular Weight | 298.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Resmetirom Standards
- Resmetirom Impurity 62 (CAS CATO-C4X-291262)
- Resmetirom impurity 66 (CAS CATO-C4X-291266)
- Resmetirom impurity 67 (CAS CATO-C4X-291267)
- Resmetirom Impurity 22 (CAS 125001-18-5)
- Resmetirom impurity 124 (CAS CATO-C4X-2912124)
- Resmetirom impurity 19 (CAS CATO-C4X-291219)
- Resmetirom Impurity 43 (CAS CATO-C4X-291243)
- Resmetirom Impurity 8 (CAS 1581304-46-2)
Recommended Standards
- 4-Bromo-5-((2-(cyclohex-1-en-1-yl)ethyl)amino)pyridazin-3(2h)-one (CAS 1008351-60-7)
- 1-(4-Bromobenzyl)piperidine-2-carboxylic acid (CAS 1024026-28-5)
- N-Boc-4-bromoisoindoline (CAS 1035235-27-8)
- Palbociclib Impurity 153 (CAS CATO-C4X-1125153)
- Sildenafil Impurity 286 (CAS CATO-C4X-1128286)
- Labetalol Impurity 25 (CAS CATO-C4X-246625)
- Baloxavir Marboxil Impurity 193 (CAS 2591558-80-2)
- Methyl 2,3-dimethyl-5-nitrobenzoate (CAS 90922-71-7)
- 2-Amino-5-(1,3-dioxolan-2-yl)pentanoic acid (CAS 170242-34-9)
- 2'-(Methylsulfonyl)-7',8'-dihydro-5'H-spiro[cyclopropane-1,6'-pyrido[3,4-d]pyrimidine] (CAS 2766053-52-3)
- (5R)-5,6-Dihydro-5-(1-methylethyl)-2-(2,3,4,5,6-pentafluorophenyl)-8H-1,2,4-triazolo[3,4-c][1,4]oxaziniumTetrafluoroborate (CAS 2254501-59-0)
- 1-(2-Hydroxyphenyl)-3-(2-methoxyphenyl)propane-1,3-dione (CAS 6310-45-8)
- Norepinephrine Impurity 64 (CAS CATO-C4X-151464)
- Tirzepatide Impurity 24 X TFA Salt (CAS CATO-C4X-324024)
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