Roflumilast Impurity C65 CAS 162401-60-7
| CAS No. | 162401-60-7 |
| Molecular Formula | C9H6F4O4 |
| Molecular Weight | 254.14 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Roflumilast Impurity C65 (C9H6F4O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Roflumilast Impurity C65 (CAS 162401-60-7) is a certified pharmaceutical impurity reference standard with the molecular formula C9H6F4O4 and a molecular weight of 254.14 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Roflumilast Impurity C65 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H6F4O4 |
| Molecular Weight | 254.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2003 |
| Halogen Content | F-containing |
Related Roflumilast Standards
- Roflumilast Impurity 44 (CAS CATO-C4X-108444)
- Roflumilast impurity 15 (CAS 162401-69-6)
- Roflumilast Impurity 33 (CAS 2376345-94-5)
- Roflumilast Impurity 34 (CAS 1882067-44-8)
- Roflumilast USP Related Compound D (CAS 162401-62-9)
- Roflumilast Impurity 43 (CAS CATO-C4X-108443)
- Roflumilast impurity 23 (CAS 1369817-76-4)
- Roflumilast Impurity 58 (CAS CATO-C4X-193558)
Recommended Standards
- 3,5-Bis(difluoromethoxy)benzoic acid (CAS 1432678-93-7)
- 4-(Fluoromethyl)-2-methyl-5-nitro-3-(trifluoromethoxy)pyridine (CAS 1806032-07-4)
- Dacomitinib Impurity 53 (CAS CATO-C4X-208653)
- 1,1,1-Trifluoro-2-(2-fluoropyridin-3-yl)-3-nitropropan-2-ol (CAS 892414-45-8)
- Zanamivir Impurity 11 (CAS CATO-C4X-205011)
- Cloxacillin Impurity 32 (CAS CATO-C4X-159732)
- Methylergometrine Impurity 7 (CAS CATO-C4X-19487)
- 6,8-Difluoro-4-methylumbelliferyl beta-D-glucopyranoside, 98% (CAS 351009-26-2)
- 4,4'-(((Oxybis(ethane-2,1-diyl))bis(oxy))bis(4,1-phenylenesulfonyl))diphenol (CAS 29239-85-8)
- 7-Bromo-5-(methylthio)-1H-benzo[d]imidazole (CAS 1805883-57-1)
- (R)-(5-METHYL-4,5-DIHYDRO-1H-PYRAZOL-1-YL)(PYRIDIN-3-YL)METHANONE (CAS 130775-79-0)
- 2-(4-Chloro-3-methylphenyl)pentan-2-ol (CAS 1379313-33-3)
- 3-(3-Nitrophenyl)acrylonitrile (CAS 87259-18-5)
- Semaglutide impurity 76 (CAS CATO-C4X-222676)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com