Roflumilast Impurity 43 CAS CATO-C4X-108443
| CAS No. | CATO-C4X-108443 |
| Molecular Formula | C10H10F2O3S |
| Molecular Weight | 248.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Roflumilast Impurity 43 (CAS CATO-C4X-108443, C10H10F2O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Roflumilast Impurity 43 (C10H10F2O3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 248.25 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10F2O3S |
| Molecular Weight | 248.25 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Roflumilast Standards
- Roflumilast impurity 23 (CAS 1369817-76-4)
- Roflumilast Impurity 37 (CAS CATO-C4X-108437)
- Roflumilast Impurity C65 (CAS 162401-60-7)
- Roflumilast impurity 17 (CAS 151103-09-2)
- Roflumilast impurity 21 (CAS 162401-78-7)
- Roflumilast Impurity 41 (CAS 1882067-43-7)
- Roflumilast Impurity 44 (CAS CATO-C4X-108444)
- Roflumilast impurity 15 (CAS 162401-69-6)
Recommended Standards
- Tenosal (CAS 95232-68-1)
- Pilocarpine EP Impurity B Sodium Salt (CAS 92598-79-3)
- N-Ethyl-2-(3-fluorophenyl)-5-methyloxazole-4-carboxamide (CAS 69382-13-4)
- 2-(Benzoylamino)-1,3-thiazole-4-carboxylic acid (CAS 1022011-51-3)
- Cinitapride Impurity 25 (CAS CATO-C4X-290825)
- Carbamazepine Impurity 33 (CAS 34124-14-6)
- Fluocinolone Acetonide Impurity 15 (CAS 1181-32-4)
- N1,N1,N3-triphenylbenzene-1,3-diamine (CAS 1554227-26-7)
- 2-(3-Chloro-4-fluorobenzenesulfonyl)-3H-benzo[f]chromen-3-one (CAS 866346-87-4)
- 5-(3-Ethoxy-4-propoxybenzylidene)-2-(p-tolyl)thiazolo[3,2-b][1,2,4]triazol-6(5H)-one (CAS 617694-32-3)
- Fluvoxamine impurity 43 (CAS CATO-C4X-195143)
- 1T086B9Q1J 74839-84-2 Chiraphos, (R,R)- UNII-1T086B9Q1J (2R,3R)-Bis(diphenylphosphino)butane (R,R)-Chiraphos Cira Phosphine, 1,1'-((1R,2R)-1,2-dimethyl-1,2-ethanediyl)bis(1,1-diphenyl- (CAS 74839-84-2)
- Selexipag Impurity 16 (CAS CATO-C4X-196116)
- Semaglutide Impurity 82 (CAS CATO-C4X-222682)
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