Ticagrelor Impurity 154 HCl CAS 1643378-58-8
| CAS No. | 1643378-58-8 |
| Molecular Formula | C9H10FN |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ticagrelor Impurity 154 HCl (C9H10FNHCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Ticagrelor Impurity 154 HCl (CAS 1643378-58-8), a pharmacopoeial impurity reference standard (molecular formula C9H10FNHCl, MW 187.64 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H10FN HCl |
| Molecular Weight | 187.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Ticagrelor Standards
- Ticagrelor Impurity N40 (CAS 1006376-60-8)
- Ticagrelor Impurity 88 (CAS 1006376-61-9)
- Ticagrelor Impurity 152 (CAS 1006376-62-0)
- Ticagrelor Impurity 121 (CAS 1006614-49-8)
- Ticagrelor impurity 84（trans） (CAS 1006614-51-2)
- Ticagrelor Impurity 113 (CAS 1156575-52-8)
- Ticagrelor impurity 161 (CAS 1157692-93-7)
- Ticagrelor Impurity 168 (CAS 1207276-00-3(free base))
Recommended Standards
- Hydroxychloroquine Impurity 38 (CAS 6823-83-2)
- Nintedanib Impurity 116 (CAS CATO-C4X-1814116)
- Elobixibat Impurity 50 (CAS 358375-95-8)
- 1,4,5,6-Tetrahydrocyclopenta[c]pyrazol-3-ol (CAS 4344-74-5)
- 4-Isopropoxy-N-(5-methylisoxazol-3-yl)benzamide (CAS 681236-43-1)
- 5-Iodo-4-methyl-2-(methylsulfonyl)pyrimidine (CAS 2089320-66-9)
- Adaprolol maleate (CAS 121009-31-2)
- 6-Cyano-4-(difluoromethyl)-5-methoxypyridine-3-sulfonyl chloride (CAS 1807118-43-9)
- Methyl 4-bromo-2-chloro-5-methoxybenzoate (CAS 1427437-60-2)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com