Dexamethasone EP Impurity F CAS 382-67-2
| CAS No. | 382-67-2 |
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Dexamethasone EP Impurity F (CAS 382-67-2, C22H29FO4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Dexamethasone EP Impurity F (C22H29FO4) contains a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 376.46 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dexamethasone EP Impurity F meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone Impurity 43 (CAS CATO-C4X-116543)
- Dexamethasone Isonicotinate EP Impurity C (CAS 426-15-3)
- Dexamethasone sodium phosphate EP Impurity G (CAS 37927-01-8)
- Dexamethasone Desfluoro 11-Epimer (CAS 78761-59-8)
- Dexamethasone Oxetanone (CAS 4089-36-5)
- Dexamethasone Impurity 104 (CAS 62800-49-1)
- Dexamethasone Impurity 120 (CAS CATO-C4X-1165120)
- Dexamethasone Impurity 23 (CAS 59860-99-0)
Recommended Standards
- Betamethasone Impurity 125 (CAS CATO-C4X-1437125)
- Betamethasone Valerate EP Impurity B (CAS 1879-77-2)
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- 6-beta-Methyl Fluorometholone (CAS 3918-13-6)
- Benidipine Impurity 26 (CAS CATO-C4X-112026)
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- Tiotropium Bromide EP Impurity B (CAS 136310-64-0)
- 5-Amino-4-(sec-butyl)-1H-pyrazol-3(2H)-one (CAS 857988-45-5)
- n-(Prop-2-yn-1-yl)-2-(4-(2,2,2-trifluoroethyl)piperazin-1-yl)acetamide (CAS 1311833-18-7)
- 2-Amino-4-cyclopropoxybenzoic acid (CAS 1243409-36-0)
- 5-(2,6-Difluorophenyl)-2-(trifluoromethyl)furan-3-carbonyl chloride (CAS 242812-03-9)
- 1-Amino-5-oxopyrrolidine-3-carbohydrazide (CAS 98069-97-7)
- (2Z)-3-(4-Chlorophenyl)-1-(4-methylpiperazin-1-yl)prop-2-en-1-one (CAS 1164473-11-3)
- C-Peptide 1 (rat) (CAS 41475-27-8)
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