Dexamethasone Isonicotinate EP Impurity C CAS 426-15-3
| CAS No. | 426-15-3 |
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Dexamethasone Isonicotinate EP Impurity C (CAS 426-15-3), a pharmacopoeial impurity reference standard (molecular formula C22H29FO4, MW 376.46 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Dexamethasone Isonicotinate EP Impurity C (C22H29FO4) is characterized by a flavonoid core, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H29FO4 |
| Molecular Weight | 376.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone Impurity 43 (CAS CATO-C4X-116543)
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- Dexamethasone Impurity 104 (CAS 62800-49-1)
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- Dexamethasone Impurity 23 (CAS 59860-99-0)
Recommended Standards
- 2-[(5-amino-1,3,4-thiadiazol-2-yl)sulfanyl]-N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)acetamide (CAS 329921-17-7)
- Betamethasone Impurity 125 (CAS CATO-C4X-1437125)
- (11α,16α,17β)Androsta-1,4-diene-17-carboxylic acid, 9-fluoro-11-hydroxy-16-methyl-3-oxo-methyl EsterDISCONTINUED. Please see A653305 (CAS 85617-70-5)
- Betamethasone Valerate EP Impurity B (CAS 1879-77-2)
- Bevantolol Impurity 27 (CAS CATO-C4X-241127)
- Lesinurad Impurity 15 (CAS 25033-19-6)
- Lodoxamide lmpurity 11 (CAS 67451-38-1)
- N-Methyl-4-(pyrazin-2-yl)piperazine-1-carboxamide (CAS 89007-30-7)
- 2-Ethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (CAS 1596338-61-2)
- (1S,2S)-3-oxocyclobutane-1,2-dicarboxylic acid (CAS 2231664-50-7)
- Benzyl (3S,5R)-3-amino-5-methylpiperidine-1-carboxylate (CAS 1792250-69-1)
- 3,5-Di-tert-butyl-N-(6-(dimethylamino)-1-(4-fluorophenyl)-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-hydroxybenzamide (CAS 595558-89-7)
- 2-(4-Methoxyphenyl)-2-(3-(trifluoromethyl)quinoxalin-2-yl)acetonitrile (CAS 477867-64-4)
- Des-[Oct-γ-Glu-AEEA-AEEA]-Semaglutide (CAS CATO-C4X-2226112)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com