Dexamethasone Impurity 25 CAS 1880-61-1
| CAS No. | 1880-61-1 |
| Molecular Formula | C20H25FO3 |
| Molecular Weight | 332.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dexamethasone Impurity 25 (CAS 1880-61-1) is a certified pharmaceutical impurity reference standard with the molecular formula C20H25FO3 and a molecular weight of 332.41 g/mol.
Dexamethasone Impurity 25 (C20H25FO3) contains a steroid core, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Dexamethasone Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H25FO3 |
| Molecular Weight | 332.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Dexamethasone Standards
- Dexamethasone Impurity 92 (CAS 2285-53-2)
- Dexamethasone Impurity 59 (CAS CATO-C4X-116559)
- Dexamethasone Impurity 93 (CAS 83509-38-0)
- Dexamethasone EP Impurity K (CAS 1809224-82-5)
- Dexamethasone EP Impurity E (CAS 13209-41-1)
- Dexamethasone Impurity 94 (CAS 59861-00-6)
- Dexamethasone Impurity 33 (CAS 75262-69-0)
- Dexamethasone impurity 89 (CAS CATO-C4X-116589)
Recommended Standards
- Oxitropium bromide EP Impurity C (CAS 99571-64-9)
- Isopropyl 3-phenyl-3-(phenylsulfonyl)propanoate (CAS 2376300-52-4)
- Clobetasol Propionate Impurity 12 (CAS 3109-01-1)
- Betamethasone Impurity 10 (CAS 38680-83-0)
- Bisoprolol Impurity 113 (CAS CATO-C4X-1247113)
- Granisetron Impurity 14 (CAS CATO-C4X-197014)
- Olopatadine Impurity 47 (CAS 872040-99-8)
- 3-(((3-Hydroxypropyl)amino)methyl)benzonitrile (CAS 1042551-80-3)
- Ethyl 4-chloro-5-(trifluoromethyl)quinoline-3-carboxylate (CAS 2177266-12-3)
- 6-Bromo-4-chloro-2-cyclopropylquinazoline (CAS 1697446-45-9)
- 1-Chloro-3-(1,3,3-trimethyl-2,3-dihydro-1H-indol-2-ylidene)propan-2-one (CAS 92297-75-1)
- N-(4-Methoxyphenyl)-4-methylbenzenesulfonamide (CAS 1150-26-1)
- 2-(4-Butoxyphenyl)-6,8-dimethylquinoline-4-carbonyl chloride (CAS 1160262-93-0)
- C-Peptide (human) (CAS 33017-11-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com