Roflumilast impurity 24 CAS 1895-39-2

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.1895-39-2
Molecular FormulaC2ClF2O2
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Roflumilast impurity 24 CAS 1895-39-2 chemical structure

Description

Owing to a salt form, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, Roflumilast impurity 24 is typically white to off-white crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 152.46 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

As a process- or degradation-related impurity, Roflumilast impurity 24 (CAS 1895-39-2, C2ClF2O2Na) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC2ClF2O2 Na
Molecular Weight152.46 g/mol
Purity97%+
StorageStore at 2-8°C, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityStable under recommended storage conditions
Degree of Unsaturation (DBE)1.5
CAS Registry Year (est.)1957
Halogen ContentF/Cl-containing

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