Olaparib Impurity 77 CAS 1937362-45-2
| CAS No. | 1937362-45-2 |
| Molecular Formula | C8H6FN3 |
| Molecular Weight | 163.15 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Olaparib Impurity 77 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Olaparib Impurity 77 (CAS 1937362-45-2, C8H6FN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Olaparib Impurity 77 (C8H6FN3) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Olaparib Impurity 77 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H6FN3 |
| Molecular Weight | 163.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Olaparib Standards
- Olaparib impurity 144 (CAS CATO-C4X-1135144)
- Olaparib Impurity 60 (CAS CATO-C4X-113560)
- Olaparib Impurity 80 (CAS 4122-56-9)
- Olaparib Impurity 81 (CAS 4122-57-0)
- Olaparib Impurity 73 (CAS 164149-28-4)
- Olaparib Impurity 33 (CAS 550363-85-4)
- Olaparib Impurity 104 (CAS 545348-09-2)
- Olaparib Impurity 64 (CAS 155295-47-9)
Recommended Standards
- Diethyl Malonate-13C3 (CAS 53051-81-3)
- Blonanserin Impurity 33 (CAS 4640-67-9)
- <SC>L</SC>-Glutamine-<SUP>13</SUP>C<SUB>5</SUB>,<SUP>15</SUP>N<SUB>2</SUB>,d <SUB>10</SUB> (CAS 1217443-24-7)
- 3-(2-Fluorophenyl)-3-oxopropanenitrile (CAS 31915-26-1)
- Nifuroxazide EP Impurity D (CAS 112537-96-9)
- Apalutamide Impurity 43 (CAS 1513700-34-9)
- Miconazole EP Impurity I (CAS 24169-00-4)
- N-(2-(phenylthio)ethyl)prop-2-en-1-amine (CAS 188642-29-7)
- Piperazine-2,2,3,3,5,5,6,6-d (CAS 314062-45-8)
- {3-[3-(ethylcarbamoyl)phenyl]phenyl}acetic acid (CAS 1375069-13-8)
- D-Ormeloxifene (CAS 78994-25-9)
- 4-(Hydroxymethyl)-2,3,5,6-tetrafluoropyridine (CAS 24191-31-9)
- 4-(((2-Methoxynaphthalen-1-yl)methylene)amino)-3-(2-methoxyphenyl)-1H-1,2,4-triazole-5(4H)-thione (CAS 497920-36-2)
- Semaglutide Impurity 16 (CAS CATO-C4X-222616)
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