Furosemide Impurity 57 CAS 19377-82-3
| CAS No. | 19377-82-3 |
| Molecular Formula | C10H9NO2 |
| Molecular Weight | 175.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Furosemide Impurity 57.
Furosemide Impurity 57 (CAS 19377-82-3) is a certified pharmaceutical impurity reference standard with the molecular formula C10H9NO2 and a molecular weight of 175.18 g/mol.
The molecular framework of Furosemide Impurity 57 (C10H9NO2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Furosemide Impurity 57 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9NO2 |
| Molecular Weight | 175.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Nitrogen Atoms | 1 |
Related Furosemide Standards
- Furosemide Impurity 33 (CAS 1803102-41-1)
- Furosemide Impurity 49 (CAS CATO-C4X-140249)
- Furosemide Impurity 32 (CAS 18240-50-1)
- Furosemide Impurity 57 (CAS 5428-37-5)
- Furosemide EP Impurity E (CAS 50-84-0)
- Furosemide Impurity 41 (CAS 137-65-5)
- Furosemide Impurity 34 (CAS 6660-65-7)
- Furosemide Impurity 21 (CAS 30170-04-8)
Recommended Standards
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- Empagliflozin Impurity 9 (CAS CATO-C4X-10659)
- Medroxyprogesterone Impurity 15 (CAS CATO-C4X-145715)
- Tenofovir alafenamide Impurity 52 (CAS 383365-04-6)
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