Tucatinib Impurity 44 CAS 197382-76-6
| CAS No. | 197382-76-6 |
| Molecular Formula | C8H9N3 |
| Molecular Weight | 147.18 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Tucatinib Impurity 44 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies Tucatinib Impurity 44 (CAS 197382-76-6), a pharmacopoeial impurity reference standard (molecular formula C8H9N3, MW 147.18 g/mol) used for the identification and quantification of trace impurities in APIs.
Tucatinib Impurity 44 (C8H9N3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group. Its physicochemical properties are representative of its class; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9N3 |
| Molecular Weight | 147.18 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2013 |
| Nitrogen Atoms | 3 |
Related Tucatinib Standards
- Tucatinib Impurity 43 (CAS CATO-C4X-260543)
- Tucatinib Impurity N5 (CAS 4706-13-2)
- Tucatinib Impurity 66 (CAS CATO-C4X-260566)
- Tucatinib Impurity 48 (CAS CATO-C4X-260548)
- Tucatinib Impurity 23 (CAS 920966-13-8)
- Tucatinib Impurity 22 (CAS 920966-03-6)
- Tucatinib Impurity 6 (CAS CATO-C4X-26056)
- Tucatinib Impurity 29 (CAS CATO-C4X-260529)
Recommended Standards
- Iopromide Impurity 19 (CAS CATO-C4X-183219)
- Carbazochrome Impurity N8 (CAS 130570-60-4)
- Ziprasidone Impurity 45 (CAS 79173-62-9)
- 1-Methyl-1H-benzo[d]imidazol-2-amine (CAS 1622-57-7)
- Irbesartan Impurity 26 (CAS CATO-C4X-166626)
- Clemastine Impurity 37 (CAS CATO-C4X-183737)
- N-Nitroso Nerandomilast impurity 1 (CAS CATO-C4X-34731)
- 3-Hydroxy-7-methyl-2,3-dihydrocyclopenta[b]indole-5,8(1H,4H)-dione (CAS 261163-69-3)
- N'-[(1E)-[4-(Cyclohexylsulfanyl)-3-nitrophenyl]methylidene]-2-(phenylamino)acetohydrazide (CAS 329777-97-1)
- 2-Bromo-N-(4-chlorobenzyl)prop-2-en-1-amine (CAS 1178438-59-9)
- H-arg(Z)2-oh (CAS 4125-79-5)
- 2,4-Difluoro-3'-morpholinomethyl benzophenone (CAS 898792-28-4)
- 3-((2-Amino-6-chloropyrimidin-4-yl)amino)-5-(hydroxymethyl)cyclopentane-1,2-diol (CAS 50619-38-0)
- Semaglutide impurity 271 (CAS CATO-C4X-2226271)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com