Aprepitant impurity 61 CAS 889852-02-2
| CAS No. | 889852-02-2 |
| Molecular Formula | C30H28F7N4O6P |
| Molecular Weight | 704.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Aprepitant impurity 61 (CAS 889852-02-2) is a certified pharmaceutical impurity reference standard with the molecular formula C30H28F7N4O6P and a molecular weight of 704.53 g/mol.
Owing to a steroid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution, Aprepitant impurity 61 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 704.53 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Aprepitant impurity 61 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H28F7N4O6P |
| Molecular Weight | 704.53 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant Impurity 73 (CAS CATO-C4X-114173)
- Aprepitant Impurity 15 (CAS CATO-C4X-116815)
- Aprepitant Impurity 68 (CAS CATO-C4X-114168)
- Aprepitant impurity 65 (CAS CATO-C4X-114165)
- Aprepitant Impurity 79 (CAS CATO-C4X-114179)
- Aprepitant impurity 47 (CAS 172673-20-0)
- Aprepitant EP Impurity B (CAS 2348441-62-1)
- Aprepitant EP Impurity C (CAS 2348441-63-2)
Recommended Standards
- Lifitegrast Impurity 125 (CAS CATO-C4X-2409125)
- 4,4'-Disulfanediylbis(5-amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile) (CAS 130755-46-3)
- Fosaprepitant Impurity 12 (CAS 2035475-10-4)
- ((2S,6R)-6-(2-Isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate (CAS 956139-25-6)
- Trelagliptin impurity 87 (CAS 2270843-82-6)
- Peramivir Impurity 118 (CAS CATO-C4X-1833118)
- Edoxaban Impurity 18 (CAS CATO-C4X-106318)
- N-(2-(1H-indol-3-yl)ethyl)-3-(2-chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxamide (CAS 920700-26-1)
- (1H-indol-3-yl)methanamine oxalate (CAS 296775-93-4)
- 6-Oxobicyclo[2.2.1]heptane-2-carboxamide (CAS 1378260-01-5)
- N-{2-[(4-chlorophenyl)sulfanyl]-5-cyanophenyl}-3-(trifluoromethyl)benzamide (CAS 303147-33-3)
- 3-(2,4-Dimethylphenyl)-3-trifluoromethyl-propiophenone (CAS 898794-32-6)
- 2-(4-Ethyl-2,3-dioxopiperazin-1-yl)-N-(4-fluorophenyl)acetamide (CAS 868680-42-6)
- Liraglutide(10-22)TFA Salt (CAS CATO-C4X-199211)
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