Fosaprepitant Impurity 22 CAS CATO-C4X-116822
| CAS No. | CATO-C4X-116822 |
| Molecular Formula | C30H28F7N4O6P |
| Molecular Weight | 704.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Fosaprepitant Impurity 22 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Fosaprepitant Impurity 22 (CAS CATO-C4X-116822) is a certified pharmaceutical impurity reference standard with the molecular formula C30H28F7N4O6P and a molecular weight of 704.53 g/mol.
The molecular framework of Fosaprepitant Impurity 22 (C30H28F7N4O6P) is characterized by a steroid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C30H28F7N4O6P |
| Molecular Weight | 704.53 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Fosaprepitant Standards
- Fosaprepitant Impurity 12 (CAS 2035475-10-4)
- Fosaprepitant Impurity 42 (CAS CATO-C4X-116842)
- Fosaprepitant Impurity 44 (CAS CATO-C4X-116844)
- Fosaprepitant Impurity 45 (CAS CATO-C4X-116845)
- Fosaprepitant Impurity 34 (CAS CATO-C4X-116834)
- Fosaprepitant Impurity 52 (CAS CATO-C4X-116852)
- Fosaprepitant impurity 10 (CAS CATO-C4X-116810)
- Fosaprepitant Impurity 35 (CAS CATO-C4X-116835)
Recommended Standards
- Tosufloxacin impurity 5 (CAS CATO-C4X-19765)
- Aprepitant Impurity 73 (CAS CATO-C4X-114173)
- (2S)-5,7-Dihydroxy-2-[4-[2,4,6-Trihydroxy-3-[(E)-3-(4-Hydroxyphenyl)Prop-2-Enoyl]-5-[(2S,3R,4R,5S,6R)-3,4,5-Trihydroxy-6-(Hydroxymethyl)Oxan-2-Yl]Phenoxy]Phenyl]Chroman-4-One (CAS 77782-91-3)
- Aprepitant impurity 61 (CAS 889852-02-2)
- Procaine Impurity 22 (CAS CATO-C4X-262322)
- N-Nitroso-Isoprenaline Impurity A (CAS CATO-C4X-277530)
- Fluvastatin EP Impurity B (CAS 194934-96-8)
- 5-Methyl-6-phenoxypyridin-3-amine (CAS 1248608-03-8)
- 2-Hydrazinyl-7-(p-tolyl)thieno[3,2-d]pyrimidin-4(3H)-one (CAS 1779132-43-2)
- 2-((5-Benzyl-4-phenyl-4H-1,2,4-triazol-3-yl)thio)-N-(o-tolyl)acetamide (CAS 332907-27-4)
- (R)-1-(4-Isopropylfuran-2-yl)ethanamine (CAS 608537-88-8)
- 2-(Aminomethyl)-3-(difluoromethyl)-4-(trifluoromethoxy)-5-(trifluoromethyl)pyridine (CAS 1805092-85-6)
- 1,2-Di-p-tolylethyne (CAS 2789-88-0)
- 149471-11-4 Neuropeptide DF2 L-Phenylalaninamide, L-alpha-aspartyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-arginyl- Asp-arg-asn-phe-leu-arg-phe-NH2 Aspartyl-arginyl-asparaginyl-phenylalanyl-leucyl-arginyl-phenylalaninamide L-alpha-Aspartyl-L-arginyl-L-asparaginyl-L-phenylalanyl-L-leucyl-L-arginyl-L-phenylalaninamide DF(2) Neuropeptide Drnflrfamide (CAS 149471-11-4)
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