Aprepitant Impurity 33 CAS 219821-37-1
| CAS No. | 219821-37-1 |
| Molecular Formula | C24H25F7N4O4 |
| Molecular Weight | 566.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Aprepitant Impurity 33 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Aprepitant Impurity 33 (CAS 219821-37-1, C24H25F7N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Aprepitant Impurity 33 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 566.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H25F7N4O4 |
| Molecular Weight | 566.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2019 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant impurity 62 (CAS CATO-C4X-114162)
- Aprepitant Impurity 12 (CAS 172673-23-3)
- Aprepitant impurity 64 (CAS CATO-C4X-114164)
- Aprepitant Impurity 10 (CAS 1651828-04-4)
- Aprepitant D4 (CAS 1133387-60-6)
- rac-Aprepitant-d4 (and enantiomer) (CAS CATO-C4X-114140)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant (CAS 170729-80-3)
Recommended Standards
- Clindamycin Phosphas Impurity 42 (CAS CATO-C4X-134142)
- Cefazedone Impurity 4 (CAS CATO-C4X-11714)
- Pyrroside B (CAS 116271-35-3)
- Methyl 2-(4-(2,4-dichlorophenoxy)butanamido)-4-methyl-5-((3-nitrophenyl)carbamoyl)thiophene-3-carboxylate (CAS 335409-25-1)
- Atrasentan Impurity 40 (CAS 178738-92-6)
- Rocuronium impurity 66 (CAS 930092-99-2)
- Telmisartan EP Impurity A (CAS 1282554-35-1)
- (S)-6-Amino-2-((S)-2-(2-aminoacetamido)-3-(1H-imidazol-4-yl)propanamido)hexanamide (CAS 68984-73-6)
- Methyl 2-(6-Bromobenzofuran-3(2H)-ylidene)acetate (CAS 2091562-32-0)
- 2-(3-(Chloromethyl)phenyl)thiazole (CAS 906352-60-1)
- N-Methoxy-N-methylcyclohexanecarboxamide (CAS 80783-98-8)
- N-Methyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzamide (CAS 62347-13-1)
- 5-(((6-Chloropyridin-3-yl)methyl)thio)-4h-1,2,4-triazol-3-amine (CAS 1094626-28-4)
- Semaglutide impurity 61 (CAS CATO-C4X-222661)
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