Aprepitant Impurity 12 CAS 172673-23-3
| CAS No. | 172673-23-3 |
| Molecular Formula | C23H21F7N4O4 |
| Molecular Weight | 550.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Aprepitant Impurity 12 (CAS 172673-23-3) is a certified pharmaceutical impurity reference standard with the molecular formula C23H21F7N4O4 and a molecular weight of 550.43 g/mol.
Aprepitant Impurity 12 (C23H21F7N4O4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Aprepitant Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H21F7N4O4 |
| Molecular Weight | 550.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant impurity 64 (CAS CATO-C4X-114164)
- Aprepitant Impurity 10 (CAS 1651828-04-4)
- Aprepitant D4 (CAS 1133387-60-6)
- rac-Aprepitant-d4 (and enantiomer) (CAS CATO-C4X-114140)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant (CAS 170729-80-3)
- Aprepitant USP Related Compound A (CAS 1148113-53-4)
- Aprepitant Impurity 2 (CAS 1185502-97-9)
Recommended Standards
- tert-butyl 4-(1-(phenylsulfonyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazole-1-carboxylate (CAS 1147998-42-2)
- Hexabutoxy-μ-oxodititanium(IV),97% (CAS 7393-46-6)
- 4-(4-(Benzyloxy)-2-methylbenzoyl)-5-(3-bromophenyl)-3-hydroxy-1-(3-methoxypropyl)-1H-pyrrol-2(5H)-one (CAS 500146-47-4)
- BDP FL DBCO (CAS 2093197-94-3)
- Artemisinin Impurity 4 (CAS 181528-64-3)
- Betaquiline Impurity 24 (CAS CATO-C4X-116724)
- Mirogabalin Impurity 62 (CAS 2767341-19-3)
- 3-Bromo-2-(3-chloro-2,2-dimethylpropyl)thiophene (CAS 1468817-15-3)
- 4-(bromomethyl)-2-methoxy-1-methylbenzene (CAS 122488-92-0)
- (3S,5R)-5-aminotetrahydropyran-3-ol (CAS 1932174-95-2)
- tert-Butyl 4-(thiazol-5-yl)piperazine-1-carboxylate (CAS 2641467-20-9)
- 3-Amino-2-fluorobenzonitrile (CAS 873697-68-8)
- 1-Ethyl-2-propyl-1H-indol-5-amine (CAS 748110-18-1)
- Semaglutide impurity 39 (CAS CATO-C4X-222639)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com