Aprepitant impurity 62 CAS CATO-C4X-114162
| CAS No. | CATO-C4X-114162 |
| Molecular Formula | C24H25F7N4O4 |
| Molecular Weight | 566.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Aprepitant impurity 62 (CAS CATO-C4X-114162, C24H25F7N4O4) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Aprepitant impurity 62 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 566.47 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C24H25F7N4O4 |
| Molecular Weight | 566.47 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant Impurity 33 (CAS 219821-37-1)
- Aprepitant Impurity 12 (CAS 172673-23-3)
- Aprepitant impurity 64 (CAS CATO-C4X-114164)
- Aprepitant Impurity 10 (CAS 1651828-04-4)
- Aprepitant D4 (CAS 1133387-60-6)
- rac-Aprepitant-d4 (and enantiomer) (CAS CATO-C4X-114140)
- Aprepitant-13C2,d2 (Major) (CAS 1217676-37-3)
- Aprepitant (CAS 170729-80-3)
Recommended Standards
- Cefazedone Impurity 4 (CAS CATO-C4X-11714)
- Methyl 2-(4-(2,4-dichlorophenoxy)butanamido)-4-methyl-5-((3-nitrophenyl)carbamoyl)thiophene-3-carboxylate (CAS 335409-25-1)
- Clindamycin Phosphas Impurity 42 (CAS CATO-C4X-134142)
- 4-Glutathionyl Cyclophosphamide (CAS 77273-67-7)
- Rivaroxaban Impurity 186 (CAS CATO-C4X-1090186)
- Ethionamide EP Impurity A (CAS 2196-13-6)
- Betamethasone impurity 100 (CAS CATO-C4X-1437100)
- 2-Chloro-5-(3-nitrophenyl)oxazole (CAS 1420998-76-0)
- 2-(2-Fluoro-4-methoxyphenyl)acetonitrile (CAS 749934-29-0)
- 3-Methyl-2-(3-methylphenyl)butanenitrile (CAS 120352-95-6)
- 2-Bromo-4-methylphenyl 3-methoxybenzoate (CAS 692757-46-3)
- N-Benzyl-3-bromo-4-methylbenzenesulfonamide (CAS 850429-67-3)
- 4-Bromo-2-chloro-3-(hydroxymethyl)phenol (CAS 1255206-92-8)
- Des-Ser32-Tirzepatide (CAS CATO-CPTD788942)
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