Roflumilast Impurity 14 CAS 2206607-17-0
| CAS No. | 2206607-17-0 |
| Molecular Formula | C17H13ClF2N2O3 |
| Molecular Weight | 366.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C17H13ClF2N2O3, Roflumilast Impurity 14 contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 366.75 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Roflumilast Impurity 14 (CAS 2206607-17-0, C17H13ClF2N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H13ClF2N2O3 |
| Molecular Weight | 366.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Roflumilast Standards
- Roflumilast Impurity 40 (CAS CATO-C4X-108440)
- Roflumilast Impurity 7 (CAS 1391053-75-0)
- Roflumilast Impurity 57 (CAS CATO-C4X-108457)
- Roflumilast Impurity 36 (CAS CATO-C4X-108436)
- Roflumilast USP Related Compound A (CAS 475271-62-6)
- Roflumilast USP Related Compound B (CAS 1391052-76-8)
- Roflumilast Impurity 32 (CAS 1454574-39-0)
- Roflumilast Impurity 60 (CAS CATO-C4X-193560)
Recommended Standards
- 7-(4-Chlorophenyl)-2-(2,6-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridine-8-carbonitrile (CAS 860610-86-2)
- 4-[4-Chloro-6-[2-(difluoromethyl)-1-benzimidazolyl]-1,3,5-triazin-2-yl]morpholine (CAS 475111-38-7)
- Tert-butyl (S)-3-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)pyrrolidine-1-carboxylate (CAS 1417789-41-3)
- 2,3,4,6-tetra-O-acetyl-β-D-chloroglucose (CAS 66966-08-3)
- Indapamide Impurity 36 (CAS CATO-C4X-140036)
- Triamcinolone Acetonide Impurity 52 (CAS 3028309-43-2)
- Crisaborole Impurity 142 (CAS CATO-C4X-2021142)
- (8S,13S,14S,17R)-17-acetyl-13-methyl-3-oxo-2,3,6,7,8,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate (CAS 14340-04-6)
- Diethyl 1,3-phenylenedicarbamate (CAS 7450-61-5)
- 2-Methyl-3-oxo-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine-6-carbaldehyde (CAS 151163-96-1)
- 1H,2H,2aH,3H,4H-azeto[1,2-a]quinoxalin-3-one (CAS 1169869-08-2)
- Diethyl 1-(2,5-dichlorophenyl)-2-chlorovinylphosphate (CAS 2701-86-2)
- 90931-40-1 2-Chloro-N-[5-(trifluoromethyl)pyridin-2-yl]acetamide MFCD11867372 (CAS 90931-40-1)
- Tau Peptide (337-368) (Repeat 4 Domain) trifluoroacetate salt (CAS 330456-27-4)
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