Aprepitant EP Impurity B CAS 2206606-86-0
| CAS No. | 2206606-86-0 |
| Molecular Formula | C29H25F7N4O3 |
| Molecular Weight | 610.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Aprepitant EP Impurity B (CAS 2206606-86-0, C29H25F7N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C29H25F7N4O3, Aprepitant EP Impurity B contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 610.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Aprepitant EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H25F7N4O3 |
| Molecular Weight | 610.52 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant EP Impurity B (CAS 2348441-62-1)
- Aprepitant EP Impurity C (CAS 2348441-63-2)
- Aprepitant impurity 47 (CAS 172673-20-0)
- Aprepitant impurity 65 (CAS CATO-C4X-114165)
- Aprepitant Impurity 79 (CAS CATO-C4X-114179)
- Aprepitant Impurity 68 (CAS CATO-C4X-114168)
- Aprepitant impurity 62 (CAS CATO-C4X-114162)
- Aprepitant Impurity 33 (CAS 219821-37-1)
Recommended Standards
- Marbofloxacin Impurity 11 (CAS CATO-C4X-180011)
- Rutin (CAS 153-18-4)
- Quercetin 3-O-neohesperidoside (CAS 32453-36-4)
- Rhodiosin (CAS 86831-54-1)
- Ticagrelor Impurity 111 (CAS 1549834-66-3)
- Emedastine lmpurity 21 (CAS CATO-C4X-226721)
- Orforglipron impurity 22 (CAS 3047293-07-9)
- (-)-Menthone (CAS 14073-97-3)
- Tetrabutylphosphonium Tetrafluoroborate (CAS 1813-60-1)
- 3-Hydroxy-N-(3-morpholinopropyl)-2-naphthamide (CAS 10155-47-2)
- 6-(3,4-Dihydroisoquinolin-2(1H)-yl)-5-methylnicotinic acid (CAS 1355201-52-3)
- 5-fluoropyrimidine-2-sulfonyl chloride (CAS 1211537-47-1)
- Bis(2-bromo-5-((tert-butyldimethylsilyl)oxy)phenyl)dimethylsilane (CAS 2410792-90-2)
- Semaglutide impurity 50 (CAS 2773558-66-8)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com