Macitentan Impurity 16 CAS 2211059-00-4
| CAS No. | 2211059-00-4 |
| Molecular Formula | C19H21BrN6O4S |
| Molecular Weight | 509.38 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 509.38 g/mol gives Macitentan Impurity 16 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Macitentan Impurity 16 (CAS 2211059-00-4), a pharmacopoeial impurity reference standard (molecular formula C19H21BrN6O4S, MW 509.38 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Macitentan Impurity 16 (C19H21BrN6O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Macitentan Impurity 16 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C19H21BrN6O4S |
| Molecular Weight | 509.38 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 6 |
| Sulfur Atoms | 1 |
Related Macitentan Standards
- Macitentan Impurity 56 (CAS CATO-C4X-117556)
- Macitentan Impurity 21 (CAS CATO-C4X-117521)
- Macitentan Impurity 57 (CAS CATO-C4X-117557)
- Macitentan Impurity 55 (CAS CATO-C4X-117555)
- Macitentan Impurity 33 (CAS 1642873-05-9)
- Macitentan Impurity N1 (CAS 2443747-63-3)
- Macitentan Impurity 35 (CAS 441798-36-3)
- Macitentan Impurity 8 (CAS 556796-88-4)
Recommended Standards
- 4-(3-((4-(4-Bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)acrylamido)benzamide (CAS 477329-29-6)
- Deflazacort Impurity 5 (CAS 1425664-43-2)
- 4-(3-((4-(4-Bromophenyl)-5-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)thio)acrylamido)benzamide (CAS 477330-09-9)
- Morphothiadin (CAS 1092970-12-1)
- 【停用见C1650856】Pitolisant Impurity 52 (CAS CATO-C4X-252052)
- Semaglutide impurity 81 (CAS CATO-C4X-222681)
- Linaclotide Impurity 28 (CAS CATO-C4X-210628)
- 5-p-Tolyloxymethyl-3H-[1,3,4]oxadiazole-2-thione (CAS 34243-10-2)
- (R)-N-isopropylpiperidine-3-carboxamide hydrochloride (CAS 881546-40-3)
- Bis(dicyclohexylphenylphosphine)(η2-ethene)nickel (CAS 1419179-27-3)
- (3S,4R)-3-Fluoropiperidin-4-ol (CAS 1147112-69-3)
- Methyl (3-(chloromethyl)phenyl)carbamate (CAS 99233-53-1)
- L-α-Glutamyl-L-cysteinylglycine Glutathione (CAS 119290-90-3)
- Semaglutide impurity 31 (CAS CATO-C4X-222631)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com