Lotilaner Impurity 20 CAS CATO-C4X-325620
| CAS No. | CATO-C4X-325620 |
| Molecular Formula | C8H2Cl3F3O |
| Molecular Weight | 277.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Lotilaner Impurity 20 is closely related to a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Lotilaner Impurity 20 (CAS CATO-C4X-325620) is a certified pharmaceutical impurity reference standard with the molecular formula C8H2Cl3F3O and a molecular weight of 277.46 g/mol.
The molecular framework of Lotilaner Impurity 20 (C8H2Cl3F3O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Lotilaner Impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H2Cl3F3O |
| Molecular Weight | 277.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl-containing |
Related Lotilaner Standards
- Lotilaner Impurity 23 (CAS CATO-C4X-325623)
- Lotilaner Impurity 4 (CAS CATO-C4X-32564)
- Lotilaner Impurity 21 (CAS CATO-C4X-325621)
- Lotilaner Impurity 29 (CAS 2226274-70-8)
- Lotilaner Impurity 7 (CAS CATO-C4X-32567)
- Lotilaner Impurity 24 (CAS CATO-C4X-325624)
- Lotilaner Impurity 22 (CAS CATO-C4X-325622)
- Lotilaner Impurity 15 (CAS CATO-C4X-325615)
Recommended Standards
- 53012-82-1 2,6-Dichloro-3-(trifluoromethyl)benzoyl chloride MFCD11519345 (CAS 53012-82-1)
- 2,3-Dichloro-6-(trifluoromethyl)benzoyl chloride (CAS 886501-87-7)
- N,N-Diethyl-3-(triethoxysilyl)propan-1-amine (CAS 10049-42-0)
- 8-Bromo-6-chloro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylic acid (CAS 1936559-33-9)
- Minoxidil Impurity 46 (CAS 79459-05-5)
- Fulvestrant impurity 39 (CAS CATO-C4X-191739)
- Oxacillin Impurity 47 (CAS CATO-C4X-232147)
- Methyl 4-((2-(2-((4-ethylphenyl)amino)-2-oxoacetyl)hydrazono)methyl)benzoate (CAS 881683-58-5)
- 2-[[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-(ethyl)amino]-1-ethanol (CAS 1220033-21-5)
- (R)-3-(3-Isopropylpiperazin-1-yl)propanoic acid (CAS 1240588-34-4)
- [4-(2-Pyridin-3-yl-1,3-thiazol-4-yl)phenyl]amine (CAS 92165-08-7)
- 3-Amino-n-methyl-n-phenylbenzene-1-sulfonamide (CAS 6374-99-8)
- 4-(2,4-Dichlorophenyl)-5-(methylsulfanyl)-1,2,3-thiadiazole (CAS 338409-02-2)
- Insulin Degludec Impurity 13 (CAS CATO-C4X-215713)
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