Dolutegravir Impurity 59 CAS 2244245-36-9
| CAS No. | 2244245-36-9 |
| Molecular Formula | C21H22FN3O5 |
| Molecular Weight | 415.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Dolutegravir Impurity 59 (C21H22FN3O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO supplies Dolutegravir Impurity 59 (CAS 2244245-36-9), a pharmacopoeial impurity reference standard (molecular formula C21H22FN3O5, MW 415.41 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H22FN3O5 |
| Molecular Weight | 415.41 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related Dolutegravir Standards
- Dolutegravir Impurity 45 (CAS 2244245-33-6)
- Dolutegravir Impurity 49 (CAS CATO-C4X-162049)
- Dolutegravir Impurity 36 (CAS CATO-C4X-162036)
- Dolutegravir (CAS 1051375-16-6)
- Dolutegravir Impurity 1 (CAS 1357289-29-2)
- Dolutegravir Impurity 11 (CAS 1973402-05-9)
- Dolutegravir Impurity 2 (CAS 1309560-49-3)
- Dolutegravir Impurity 4 (CAS 1357289-37-2)
Recommended Standards
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- Moxifloxacin Impurity 29 (CAS 1395056-41-3)
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- Formoterol Impurity 71 (CAS 71250-20-9)
- Oseltamivir Impurity 162 (CAS CATO-C4X-1720162)
- 2,2,2-Trifluoro-N-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide (CAS 2490666-14-1)
- tert-Butyl (3-bromo-1-(2-methoxyphenyl)propyl)carbamate (CAS 924817-78-7)
- (S)-2-(2-bromo-3-methylphenyl)pyrrolidine (CAS 1213619-31-8)
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- SAYTEX RB-79 (CAS 77098-07-8)
- 1-(2-(6-Methoxypyridin-3-yl)pyrrolidin-1-yl)ethanone (CAS 1352500-16-3)
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Why CATO?
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