Nicorandil Impurity 9 CAS 2250142-71-1
| CAS No. | 2250142-71-1 |
| Molecular Formula | C16H18N5O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Nicorandil Impurity 9 (CAS 2250142-71-1, C16H18N5O5I) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Nicorandil Impurity 9 (C16H18N5O5I) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H18N5O5 I |
| Molecular Weight | 487.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 5 |
Related Nicorandil Standards
- Nicorandil N-Oxide (CAS 107833-98-7)
- Nicorandil-d4 (CAS 1132681-23-2)
- Nicorandil Impurity 7 (CAS 113743-17-2)
- Nicorandil Impurity 5 (CAS 1157-74-0)
- Nicorandil Impurity 47 (CAS 13362-26-0)
- Nicorandil Impurity 26 (CAS 14906-63-9)
- Nicorandil Impurity 24 (CAS 149415-43-0)
- Nicorandil Impurity 43 (CAS 1570-45-2)
Recommended Standards
- Tartrazine Impurity 1 (CAS 104236-31-9)
- Pregabalin Impurity 116 (CAS 1101167-84-3（free base）)
- Moxifloxacin Impurity 56 (CAS CATO-C4X-1074156)
- 4-(N-Boc-aminomethyl)phenylboronic Acid Pinacol Ester (CAS 330794-35-9)
- 4-Bromo-3,5-diethoxybenzoic acid (CAS 363166-41-0)
- 4-Bromo-5-propylthiophene-2-carboxylic acid (CAS 869951-15-5)
- Tetrahydro-2H-pyran-4-amine acetate (CAS 1005498-91-8)
- 17:0-20:4pi (5) P (CAS 1246304-69-7)
- 1-(3-Cyclohexyl-1-methyl-1h-1,2,4-triazol-5-yl)-N-methylethan-1-amine (CAS 1343242-84-1)
- Semaglutide impurity 72 (CAS CATO-C4X-222672)
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