Nicorandil Impurity 15 CAS 2250142-73-3
| CAS No. | 2250142-73-3 |
| Molecular Formula | C16H18N5O5 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Nicorandil Impurity 15 is closely related to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Nicorandil Impurity 15 (CAS 2250142-73-3, C16H18N5O5Br) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution, Nicorandil Impurity 15 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 440.25 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nicorandil Impurity 15 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18N5O5 Br |
| Molecular Weight | 440.25 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 5 |
Related Nicorandil Standards
- Nicorandil N-Oxide (CAS 107833-98-7)
- Nicorandil-d4 (CAS 1132681-23-2)
- Nicorandil Impurity 7 (CAS 113743-17-2)
- Nicorandil Impurity 5 (CAS 1157-74-0)
- Nicorandil Impurity 47 (CAS 13362-26-0)
- Nicorandil Impurity 26 (CAS 14906-63-9)
- Nicorandil Impurity 24 (CAS 149415-43-0)
- Nicorandil Impurity 43 (CAS 1570-45-2)
Recommended Standards
- Finerenone Impurity 188 (CAS CATO-C4X-2880188)
- Acotiamide Impurity 8 (CAS CATO-C4X-11148)
- Cariprazine Impurity 27 (CAS CATO-C4X-240827)
- 2-[4-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenoxy]-propionic acid ethyl ester (CAS 1311278-18-8)
- Sulfometuron (CAS 74223-56-6)
- 3-(3-Chlorophenyl)prop-2-yn-1-amine (CAS 1248691-80-6)
- 2-Aminopyridine-4-boronic Acid (CAS 903513-62-2)
- 1-(2-Chlorophenyl)-3-phenylpropan-1-one (CAS 898764-45-9)
- (2E)-1-(2,4-Dimethylphenyl)-3-(2-methoxyphenyl)prop-2-en-1-one (CAS 1287195-22-5)
- Des-Pro-Pro-Tirzepatide (CAS CATO-CPTD788696)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com