Aprepitant EP Impurity C CAS 2348441-63-2
| CAS No. | 2348441-63-2 |
| Molecular Formula | C29H25F7N4O3 |
| Molecular Weight | 610.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Aprepitant EP Impurity C (CAS 2348441-63-2) is a certified pharmaceutical impurity reference standard with the molecular formula C29H25F7N4O3 and a molecular weight of 610.52 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Aprepitant EP Impurity C is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 610.52 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C29H25F7N4O3 |
| Molecular Weight | 610.52 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant EP Impurity B (CAS 2348441-62-1)
- Aprepitant EP Impurity B (CAS 2206606-86-0)
- Aprepitant impurity 47 (CAS 172673-20-0)
- Aprepitant impurity 65 (CAS CATO-C4X-114165)
- Aprepitant Impurity 79 (CAS CATO-C4X-114179)
- Aprepitant Impurity 68 (CAS CATO-C4X-114168)
- Aprepitant impurity 62 (CAS CATO-C4X-114162)
- Aprepitant Impurity 33 (CAS 219821-37-1)
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