Aprepitant EP Impurity B CAS 2348441-62-1
| CAS No. | 2348441-62-1 |
| Molecular Formula | C29H25F7N4O3 |
| Molecular Weight | 610.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C29H25F7N4O3, Aprepitant EP Impurity B contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 610.52 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a process- or degradation-related impurity, Aprepitant EP Impurity B (CAS 2348441-62-1, C29H25F7N4O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Aprepitant EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C29H25F7N4O3 |
| Molecular Weight | 610.52 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1999 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant EP Impurity C (CAS 2348441-63-2)
- Aprepitant EP Impurity B (CAS 2206606-86-0)
- Aprepitant impurity 47 (CAS 172673-20-0)
- Aprepitant impurity 65 (CAS CATO-C4X-114165)
- Aprepitant Impurity 79 (CAS CATO-C4X-114179)
- Aprepitant Impurity 68 (CAS CATO-C4X-114168)
- Aprepitant impurity 62 (CAS CATO-C4X-114162)
- Aprepitant Impurity 33 (CAS 219821-37-1)
Recommended Standards
- Quercetin 3-O-neohesperidoside (CAS 32453-36-4)
- luteolin-7-O-gentiobiside (CAS 70855-41-3)
- Kaempferol-3,7-di-O-β-glucoside (CAS 25615-14-9)
- Marbofloxacin Impurity 11 (CAS CATO-C4X-180011)
- Chlorphenamine Impurity 7 (CAS 78180-89-9)
- Baricitinib Impurity 33 (CAS 4843-98-5)
- Hydroxychloroquine EP Impurity C Oxalate (CAS 14142-64-4)
- N-2-Hydroxyethylpiperazine-N′-ethanesulfonic Acid-d18 (CAS 203805-87-2)
- 8-(Cyclopentanecarbonyl)-3-propyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (CAS 1021212-71-4)
- 3-FLUORO-4-ANISIDINE 3-FLUORO-4-METHOXY-ANILIN 3-FLUORO-4-METHOXY-BENZENAMINE 3-FLUORO-4-METHOXY-PHENYLAMINE 3-FLUORO-P-ANISIDINE 3-Fluoro-4-methoxyaniline 366-99-4 4-AMINO-2-FLUOROANISOLE AS04085 BENZENAMINE, 3-FLUORO-4-METHOXY- PHARMABRIDGE P-3001 TIMTEC-BB SBB028264 (CAS 366-99-4)
- 2,5-Dichloroquinoxaline (CAS 55687-05-3)
- 6-amino-2-(methylsulfanyl)-5-nitroso-3,4-dihydropyrimidin-4-one (CAS 43005-49-8)
- Tert-butyl (R)-3-((5-aminopyridin-2-yl)oxy)pyrrolidine-1-carboxylate (CAS 1286207-78-0)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
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