Aprepitant impurity 47 CAS 172673-20-0
| CAS No. | 172673-20-0 |
| Molecular Formula | C23H22F7N4O6P |
| Molecular Weight | 614.41 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Aprepitant impurity 47 (CAS 172673-20-0, C23H22F7N4O6P) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C23H22F7N4O6P, Aprepitant impurity 47 contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, fluorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 614.41 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H22F7N4O6P |
| Molecular Weight | 614.41 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Aprepitant Standards
- Aprepitant EP Impurity B (CAS 2348441-62-1)
- Aprepitant EP Impurity C (CAS 2348441-63-2)
- Aprepitant EP Impurity B (CAS 2206606-86-0)
- Aprepitant impurity 65 (CAS CATO-C4X-114165)
- Aprepitant Impurity 79 (CAS CATO-C4X-114179)
- Aprepitant Impurity 68 (CAS CATO-C4X-114168)
- Aprepitant impurity 62 (CAS CATO-C4X-114162)
- Aprepitant Impurity 33 (CAS 219821-37-1)
Recommended Standards
- 2-Methoxy-1,4-dioxane (CAS 20732-36-9)
- Fosaprepitant Impurity 2 (CAS CATO-C4X-11682)
- 4-tert-Butyldimethylsilyl-5-chloro-4a-hydroxy-6-(hydroxyimino)methyl Simvastatin (CAS 123852-22-2)
- Fosaprepitant Impurity 5 (CAS CATO-C4X-11685)
- Iguratimod Impurity 7 (CAS CATO-C4X-18267)
- Thioctic acid Impurity 91 (CAS CATO-C4X-152691)
- Tegoprazan Impurity 9 (CAS 942195-91-7)
- N-(1-(6-Oxo-4-phenyl-1,6-dihydropyrimidin-2-yl)-3-(thiophen-2-yl)-1H-pyrazol-5-yl)acetamide (CAS 1207060-35-2)
- Etizolam Impurity 34 (CAS 40054-69-1)
- N-methyl-1-[1-(2-methylphenyl)-1H-tetrazol-5-yl]-1-phenylmethanamine (CAS 400747-21-9)
- 5,6,7,8-Tetrahydro-1,8-naphthyridine-2-carbaldehyde (CAS 204452-93-7)
- 2-(Chloromethyl)-5-(2,6-dichlorophenyl)pyrimidine (CAS 1361467-41-5)
- 1-(1-Phenyl-1H-tetrazol-5-yl)piperazine (CAS 198209-80-2)
- D-Thr7-Tirzepatide (CAS CATO-CPTD788924)
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